Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Populations
Characteristics | RIF Women with TAI (n = 21) | RIF Women without TAI (n = 51) | p |
---|---|---|---|
Age (years) | 33.0 (31.0–37.0) | 34.0 (31.0–38.0) | 0.490 |
BMI (kg/m2) | 21.8 (19.5–23.4) | 21.4 (20.0–22.1) | 0.848 |
TSH (uIU/mL) | 2.2 (2.0–2.5) | 2.2 (1.7–2.5) | 0.376 |
Reproductive hormone | |||
FSH (mIU/L) | 6.2 (5.7–7.2) | 6.2 (4.8–6.6) | 0.299 |
LH (mIU/L) | 4.0 (2.7–4.3) | 3.6 (2.6–4.0) | 0.587 |
E2 (pg/mL) | 38.0 (29.5–65.7) | 47.0 (30.0–64.5) | 0.828 |
PRL (ng/mL) | 30.0 (16.3–33.5) | 22.1 (15.2–33.5) | 0.554 |
T (ng/mL) | 1.1 (0.3–3.0) | 0.7 (0.3–3.0) | 0.693 |
2.2. Thyroid Function Test
2.3. Anti-Thyroid Antibodies Assay
2.4. Peripheral Blood Lymphocytes Assay
2.5. Statistical Analysis
3. Results
3.1. Prevalence of TAI in Women with RIF
3.2. Association of TAI with Thyroid Function Abnormality in Women with RIF
RIF Women with TAI (n = 21) | RIF Women without TAI (n = 51) | χ2 | p | |
---|---|---|---|---|
Thyroid function abnormality | 23.8% (5) | 13.7% (7) | 0.484 | 0.487 |
Thyroid function normality | 76.2% (16) | 86.3% (44) |
3.3. Association of TAI with Lymphocytes in Women with RIF
3.4. Association of TAI with T Subpopulations in Women with RIF
4. Discussion
5. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Huang, C.; Liang, P.; Diao, L.; Liu, C.; Chen, X.; Li, G.; Chen, C.; Zeng, Y. Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. Int. J. Environ. Res. Public Health 2015, 12, 10352-10361. https://doi.org/10.3390/ijerph120910352
Huang C, Liang P, Diao L, Liu C, Chen X, Li G, Chen C, Zeng Y. Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. International Journal of Environmental Research and Public Health. 2015; 12(9):10352-10361. https://doi.org/10.3390/ijerph120910352
Chicago/Turabian StyleHuang, Chunyu, Peiyan Liang, Lianghui Diao, Cuicui Liu, Xian Chen, Guangui Li, Cong Chen, and Yong Zeng. 2015. "Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure" International Journal of Environmental Research and Public Health 12, no. 9: 10352-10361. https://doi.org/10.3390/ijerph120910352
APA StyleHuang, C., Liang, P., Diao, L., Liu, C., Chen, X., Li, G., Chen, C., & Zeng, Y. (2015). Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure. International Journal of Environmental Research and Public Health, 12(9), 10352-10361. https://doi.org/10.3390/ijerph120910352