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Open AccessArticle

Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population

1
Department of Nephrology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, China
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Department of Nephrology, Huhhot First Hospital, Huhhot, Inner Mongolia 010010, China
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Department of Nephrology, The First Affiliated Hospital of Inner Mongolia Medical University, Huhhot, Inner Mongolia 010010, China
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Department of Nephrology, Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, Fujian 363000, China
*
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2015, 12(7), 8228-8242; https://doi.org/10.3390/ijerph120708228
Received: 3 May 2015 / Revised: 24 June 2015 / Accepted: 30 June 2015 / Published: 17 July 2015
Objective: To assess the high-sensitivity C-reactive protein (hs-CRP) levels and explore the risk factors for an elevated hs-CRP level. We also provide the clinical utility of CRP to identify subjects with metabolic syndrome (MetS). Methods: Data were drawn from a cross-sectional survey in China. Subjects were divided into three subgroups: hs-CRP ≤ 1 mg/L, 1 mg/L < hs-CRP ≤ 3 mg/L and hs-CRP > 3 mg/L. Multiple linear regressions and logistic regression models were used. Results: In the Chinese population, 50.43% subjects had a low hs-CRP level, 30.21% subjects had an intermediate hs-CRP level and 19.36% subjects had an elevated hs-CRP level. Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and urinary albumin to creatinine ratio (ACR) were correlated with log-CRP. In multivariate analysis, relative risks of an elevated CRP level were 2.40 (95% CI 1.44–3.99, p = 0.001), 3.63 (95% CI 2.20–5.98, p < 0.001), 4.23 (95% CI 2.51–7.11, p < 0.001) and 6.23 (95% CI 3.45–11.26, p < 0.001) for subjects with 1, 2, 3, or more than 3 MetS components, respectively. The accurate estimates of the area under the receiver operating characteristic of hs-CRP for MetS was 0.6954 (95% CI, 0.67–0.72). Conclusion: Age, physical inactivity, abdominal obesity, a low LDL level, an elevated fasting glucose level, uric acid and ACR are correlated with log-CRP. The number of MetS components is a significant determinant of elevated CRP levels after adjusted for other potential confounders. View Full-Text
Keywords: C-reactive protein; metabolic disorder C-reactive protein; metabolic disorder
MDPI and ACS Style

Sun, M.; Zhang, L.; Chen, S.; Liu, X.; Shao, X.; Zou, H. Association of C-Reactive Protein and Metabolic Disorder in a Chinese Population. Int. J. Environ. Res. Public Health 2015, 12, 8228-8242.

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