Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study
AbstractThe electronic cigarette (e-cig) has gained popularity as an aid in smoking cessation programs mainly because it maintains the gestures and rituals of tobacco smoking. However, it has been shown in inexperienced e-cig users that ineffective nicotine delivery can cause tobacco craving that could be responsible for unsuccessful smoking reduction/cessation. Moreover, the incorrect use of an e-cig could also led to potential nicotine overdosage and intoxication. Medically assisted training on the proper use of an e-cig plus behavioral support for tobacco dependence could be a pivotal step in avoiding both issues. We performed an eight-month pilot study of adult smokers who started e-cig use after receiving a multi-component medically assisted training program with monitoring of nicotine intake as a biomarker of correct e-cig use. Participants were tested during follow-up for breath carbon monoxide (CO), plasma cotinine and trans-3’-hydroxycotinine, and number of tobacco cigarettes smoked. At the end of the first, fourth, and eighth month of follow-up, 91.1, 73.5, and 76.5% of participants respectively were e-cig users (‘only e-cig’ and ‘dual users’). They showed no significant variation in plasma cotinine and trans-3’-hydroxycotinine with respect to the start of the study when they smoked only tobacco cigarettes, but a significant reduction in breath CO. The proposed medically assisted training program of e-cig use led to a successful nicotine intake, lack of typical cigarette craving and overdosage symptoms and a significant decrease in the biomarker of cigarette combustion products. View Full-Text
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Pacifici, R.; Pichini, S.; Graziano, S.; Pellegrini, M.; Massaro, G.; Beatrice, F. Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study. Int. J. Environ. Res. Public Health 2015, 12, 7638-7646.
Pacifici R, Pichini S, Graziano S, Pellegrini M, Massaro G, Beatrice F. Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study. International Journal of Environmental Research and Public Health. 2015; 12(7):7638-7646.Chicago/Turabian Style
Pacifici, Roberta; Pichini, Simona; Graziano, Silvia; Pellegrini, Manuela; Massaro, Giuseppina; Beatrice, Fabio. 2015. "Successful Nicotine Intake in Medical Assisted Use of E-Cigarettes: A Pilot Study." Int. J. Environ. Res. Public Health 12, no. 7: 7638-7646.