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Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome?

Department of Preventive Medicine, Lithuanian University of Health Sciences, 57-302 Šiaurės ave, Kaunas LT-49264, Lithuania
Institute of Cardiology, Lithuanian University of Health Sciences, 17 Sukilėlių ave, Kaunas LT-50009, Lithuania
Author to whom correspondence should be addressed.
Academic Editor: Paul B. Tchounwou
Int. J. Environ. Res. Public Health 2015, 12(6), 6136-6147;
Received: 21 April 2015 / Revised: 17 May 2015 / Accepted: 22 May 2015 / Published: 29 May 2015
PDF [698 KB, uploaded 29 May 2015]


Background: Mortality rates for acute coronary syndrome (ACS) patients are still very high all over the world. Our study aimed to investigate the impact of ACS treatment on cardiovascular (CV) mortality eight years following ACS. Methods: A retrospective cohort study with a total of 613 patients was used. The data was collected from databases and medical records. An evidence-based treatment (EBT) algorithm was used based on the ESC guidelines. Logistic regression analysis and standardized odds ratios with 95% confidence interval (CI) were used for the risk assessment, with a p level < 0.05 considered as significant. Results: The median follow-up time in this study was 7.6 years. During follow-up 48.9% of the patients (n = 300) died from CV and 207 (69%) for a relevant reason. For monotherapy ACE inhibitors and β-blockers, and for fixed dose combined drugs ACE inhibitors and diuretics, were most frequently used. EBT was provided to 37.8% of patients. The EBT use (HR 0.541, CI 0.394–0.742, p < 0.001) during follow-up period was important for reducing CV mortality in ACS patients. Conclusions: The combined use of EBT significantly improved outcomes. The recurrent myocardial infarction and percutaneous coronary intervention patients were more frequent in EBT and it was beneficial for reducing CV mortality. View Full-Text
Keywords: cardiovascular mortality; evidence-based treatment cardiovascular mortality; evidence-based treatment
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Umbrasienė, J.; Vanagas, G.; Venclovienė, J. Does Treatment Impact Health Outcomes for Patients After Acute Coronary Syndrome? Int. J. Environ. Res. Public Health 2015, 12, 6136-6147.

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Int. J. Environ. Res. Public Health EISSN 1660-4601 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
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