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Impact of Bisphenol A on the Cardiovascular System — Epidemiological and Experimental Evidence and Molecular Mechanisms

Department of Pharmacology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
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Int. J. Environ. Res. Public Health 2014, 11(8), 8399-8413; https://doi.org/10.3390/ijerph110808399
Received: 6 June 2014 / Revised: 28 July 2014 / Accepted: 7 August 2014 / Published: 15 August 2014
(This article belongs to the Special Issue Endocrine Disruptors and Human Health)
Bisphenol A (BPA) is a ubiquitous plasticizing agent used in the manufacturing of polycarbonate plastics and epoxy resins. There is well-documented and broad human exposure to BPA. The potential risk that BPA poses to the human health has attracted much attention from regulatory agencies and the general public, and has been extensively studied. An emerging and rapidly growing area in the study of BPA’s toxicity is its impact on the cardiovascular (CV) system. Recent epidemiological studies have shown that higher urinary BPA concentration in humans is associated with various types of CV diseases, including angina, hypertension, heart attack and coronary and peripheral arterial disease. Experimental studies have demonstrated that acute BPA exposure promotes the development of arrhythmias in female rodent hearts. Chronic exposure to BPA has been shown to result in cardiac remodeling, atherosclerosis, and altered blood pressure in rodents. The underlying mechanisms may involve alteration of cardiac Ca2+ handling, ion channel inhibition/activation, oxidative stress, and genome/transcriptome modifications. In this review, we discuss these recent findings that point to the potential CV toxicity of BPA, and highlight the knowledge gaps in this growing research area. View Full-Text
Keywords: BPA; cardiovascular; heart; mechanism BPA; cardiovascular; heart; mechanism
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Gao, X.; Wang, H.-S. Impact of Bisphenol A on the Cardiovascular System — Epidemiological and Experimental Evidence and Molecular Mechanisms. Int. J. Environ. Res. Public Health 2014, 11, 8399-8413.

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