Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides
Abstract
:1. Introduction
2. Results and Discussion
3. Experimental Section
3.1. General Experimental Procedures
3.2. Animal Material
3.3. Extraction and Separation
3.4. Cytotoxicity Testing
3.5. Neuroprotective Activity Assay
4. Conclusions
Supplementary Material
marinedrugs-09-01543-s001.pdfAcknowledgements
- Samples Availability: Not available.
References
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Position | 1, a δC, mult. | 2, b δC, mult. | 3, a δC, mult. | 4, a δC, mult. | 5, a δC, mult. |
---|---|---|---|---|---|
1 | 69.5, CH c | 73.1, CH | 59.0, CH | 118.5, CH | 121.7, CH |
2 | 36.4, CH2 | 29.4, CH2 | 25.5, CH2 | 77.8, CH | 80.8, CH |
3 | 28.8, CH2 | 24.1, CH2 | 23.3, CH2 | 30.5, CH2 | 31.1, CH2 |
4 | 36.3, CH | 30.0, CH | 32.5, CH | 29.2, CH | 33.7, CH |
5 | 48.7, C | 41.0, C | 37.6, C | 41.0, C | 40.9, C |
6 | 60.6, CH | 56.9, CH | 61.6, CH | 58.9, CH | 59.1, CH |
7 | 211.6, C | 201.8, C | 210.6, C | 107.3, C | 107.5, C |
8 | 73.7, CH | 133.9, CH | 40.3, CH2 | 33.2, CH2 | 33.4, CH2 |
9 | 111.3, CH | 143.6, CH | 78.2, CH | 27.6, CH2 | 27.4, CH2 |
10 | 156.6, C | 74.9, C | 62.8, C | 149.7, C | 145.2, C |
11 | 35.3, CH | 26.4, CH | 32.0, CH | 37.1, CH | 37.2, CH |
12 | 61.9, CH2 | 64.6, CH2 | 67.6, CH2 | 72.2, CH2 | 72.2, CH2 |
13 | 18.8, CH3 | 14.9, CH3 | 17.2, CH3 | 18.7, CH3 | 18.6, CH3 |
14 | 14.2, CH3 | 13.8, CH3 | 14.5, CH3 | 15.9, CH3 | 16.3, CH3 |
15 | 19.5, CH3 | 17.6, CH3 | 17.7, CH3 | 19.7, CH3 | 21.1, CH3 |
Position | 1, a δH (J in Hz) c | 2, b δH (J in Hz) | 3, a δH (J in Hz) | 4, a δH (J in Hz) | 5, a δH (J in Hz) |
---|---|---|---|---|---|
1 | 4.22, dd (12.0, 4.8) c | 3.81, brs | 3.31, brs | 5.57, dd (4.0, 1.6) | 5.60, brs |
2 | 2.19, dddd (14.0, 4.8, 2.4, 2.4) | 2.18, dddd (15.0, 15.0, 5.0, 3.5) | 2.19, dddd (15.6, 4.8, 2.4, 2.4) | 4.37, t (4.0) | 4.59, t (7.2) |
1.48, m | 1.65, m | 1.92, dddd (15.6, 12.0, 6.0, 1.6) | |||
3 | 1.74, ddd (14.0, 4.0, 4.0, 4.0) | 1.70, m | 1.37, m | 1.93, m | 1.84, m |
1.57, m | 1.37, m | 1.24, m | 1.57, m | 1.56, m | |
4 | 2.02, ddq (12.0, 4.0, 6.4) | 2.55, ddq (15.5, 3.5, 7.0) | 1.73, ddq (12.4, 2.8, 6.8) | 2.02, ddq (12.8, 3.2, 6.8) | 1.95, m |
6 | 2.10, brs | 2.25, d (5.0) | 2.40, m | 1.82, m | 1.80, m |
8 | 4.10, d (6.4) | 6.39, s | 2.80, dd (19.2, 2.8) | 1.94, m | 1.95, m |
2.64, dd (19.2, 2.8) | 1.82, m | 1.79, m | |||
9 | 5.77, dd (6.4, 2.4) | 6.39, s | 3.53, t (2.8) | 2.44, m; 2.30, m | 2.46, m; 2.26, m |
11 | 2.39, ddq (3.6, 3.2, 7.2) | 2.36, m | 2.38, m | 1.92, m | 1.91, m |
12 | 4.18, dd (12.0, 3.2) | 3.75, dd (12.5, 6.5) | 3.81, dd (13.2, 4.8) | 3.87, t (8.8) | 3.88, t (8.8) |
3.38, dd (12.0, 1.2) | 3.19, dd (12.5, 12.5) | 3.31, dd (13.2, 9.6) | 3.48, t (8.8) | 3.49, t (8.8) | |
13 | 1.10, d (7.2) | 0.70, d (7.0) | 0.93, d (7.2) | 1.10, d (5.2) | 1.09, d (6.0) |
14 | 0.79, d (6.4) | 0.75, d (7.0) | 0.76, d (6.8) | 0.90, d (6.8) | 0.92, d (6.8) |
15 | 0.98, s | 1.06, s | 0.87, s | 1.11, s | 1.18, s |
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Huang, C.-Y.; Su, J.-H.; Chen, B.-W.; Wen, Z.-H.; Hsu, C.-H.; Dai, C.-F.; Sheu, J.-H.; Sung, P.-J. Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides. Mar. Drugs 2011, 9, 1543-1553. https://doi.org/10.3390/md9091543
Huang C-Y, Su J-H, Chen B-W, Wen Z-H, Hsu C-H, Dai C-F, Sheu J-H, Sung P-J. Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides. Marine Drugs. 2011; 9(9):1543-1553. https://doi.org/10.3390/md9091543
Chicago/Turabian StyleHuang, Chiung-Yao, Jui-Hsin Su, Bo-Wei Chen, Zhi-Hong Wen, Chi-Hsin Hsu, Chang-Feng Dai, Jyh-Horng Sheu, and Ping-Jyun Sung. 2011. "Nardosinane-Type Sesquiterpenoids from the Formosan Soft Coral Paralemnalia thyrsoides" Marine Drugs 9, no. 9: 1543-1553. https://doi.org/10.3390/md9091543