Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents
Abstract
:1. Introduction
2. Results
2.1. The Effect of Caulerpa mexicana Extracts in vitro Production of Pro-Inflammatory Cytokines by Peritoneal Macrophages
2.2. The Effect of Different Doses of Caulerpa mexicana Extracts on Zymosan-Induced Peritonitis in Mice
2.3. The Effect of Caulerpa mexicana Extracts on the Kinetics of Zymosan-Induced Peritonitis in Mice
2.4. The Effect of Extracts of Caulerpa mexicana on Xylene-Induced Ear Edema
2.5. Effect of Caulerpa mexicana Extracts on the Zymosan-Injected Mouse Air Pouch
3. Discussion
4. Experimental
4.1. Extraction and Isolation
4.2. Animal
4.3. Peritoneal Macrophage Cell Culture
4.4. Induction of Peritonitis
4.5. Xylene-Induced Ear Edema
4.6. Mouse Air Pouch Model
5. Conclusions
Acknowledgments
References
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Groups | 15 min | 1 h | |||
---|---|---|---|---|---|
Dose (mg/kg) | Difference (mg) | Inhibition (%) | Difference (mg) | Inhibition (%) | |
Saline (i.v.) | – | 32.45 ± 2.603 | – | 31.80 ± 5.289 | – |
Methanolic | 0.4 | 7.475 ± 2.809 | 77.07% ** | 4.567 ± 2.668 | 85.63% ** |
Extract (s.c.) | 2 | 8.453 ± 3.500 | 73.55% ** | 5.167 ± 2.580 | 83.75% ** |
Aqueous | 0.4 | 4.933 ± 4.916 | 84.86% *** | 2.167 ± 3.316 | 93.18% ** |
Extract (s.c.) | 2 | 24.45 ± 5.212 | 25% | 20.07 ± 5.029 | 36.88% |
Dexa (i.p.) | 0.5 | 9.600 ± 2.419 | 70.60% ** | 8.467 ± 2.850 | 73.37% ** |
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Bitencourt, M.A.O.; Dantas, G.R.; Lira, D.P.; Barbosa-Filho, J.M.; Miranda, G.E.C.d.; Santos, B.V.d.O.; Souto, J.T. Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents. Mar. Drugs 2011, 9, 1332-1345. https://doi.org/10.3390/md9081332
Bitencourt MAO, Dantas GR, Lira DP, Barbosa-Filho JM, Miranda GECd, Santos BVdO, Souto JT. Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents. Marine Drugs. 2011; 9(8):1332-1345. https://doi.org/10.3390/md9081332
Chicago/Turabian StyleBitencourt, Mariana Angelica Oliveira, Gracielle Rodrigues Dantas, Daysianne Pereira Lira, Jose Maria Barbosa-Filho, George Emmanuel Cavalcanti de Miranda, Barbara Viviana de Oliveira Santos, and Janeusa Trindade Souto. 2011. "Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents" Marine Drugs 9, no. 8: 1332-1345. https://doi.org/10.3390/md9081332
APA StyleBitencourt, M. A. O., Dantas, G. R., Lira, D. P., Barbosa-Filho, J. M., Miranda, G. E. C. d., Santos, B. V. d. O., & Souto, J. T. (2011). Aqueous and Methanolic Extracts of Caulerpa mexicana Suppress Cell Migration and Ear Edema Induced by Inflammatory Agents. Marine Drugs, 9(8), 1332-1345. https://doi.org/10.3390/md9081332