Next Article in Journal
Marine Carotenoids: Biological Functions and Commercial Applications
Next Article in Special Issue
Deoxyuridines from the Marine Sponge Associated Actinomycete Streptomyces microflavus
Previous Article in Journal
Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2011, 9(3), 307-318;

Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa

LaFI—Laboratory of Pharmacology and Immunity, Institute of Biological Sciences and Health, Federal University of Alagoas, 57020-720, Maceió, AL, Brazil
Laboratory of Technology Pharmaceutical, Federal University of Paraíba, 58051-900, João Pessoa, PB, Brazil
Laboratory of Marine Algae, Department of Systematics and Ecology, Federal University of Paraíba, 58051-900, João Pessoa, PB, Brazil
Laboratory of Research in Natural Resources, Institute of Chemistry and Biotechnology, Federal University of Alagoas, 57072-970, Maceió, AL, Brazil
Authors to whom correspondence should be addressed.
Received: 14 January 2011 / Revised: 19 February 2011 / Accepted: 24 February 2011 / Published: 2 March 2011
(This article belongs to the Special Issue Biomedicines from Marine Symbioses)
Full-Text   |   PDF [261 KB, uploaded 24 February 2015]


Marine natural products have been the focus of discovery for new products of chemical and pharmacological interest. The aim of this study was to evaluate the antinociceptive activity of the methanolic (ME), acetate (AE), hexanic (HE) and chloroform (CE) extracts obtained from Caulerpa mexicana, and ME, CE and HE obtained from Caulerpa sertularioides. These marine algae are found all over the world, mainly in tropical regions. Models such as the writhing test, the hot plate test and formalin-induced nociception test were used to evaluate antinociceptive activity in laboratory mice. In the writhing test, all the extracts were administered orally at a concentration of 100 mg/kg, and induced high peripheral antinociceptive activity, with a reduction in the nociception induced by acetic acid above 65%. In the hot plate test, treatment with extracts from C. sertularioides (100 mg/kg, p.o.) did not significantly increase the latency of response, although the ME, AE and HE from C. mexicana showed activity in this model. This result suggests that these extracts exhibit antinociceptive activity. In the formalin test, it was observed that ME, AE and HE obtained from C. mexicana reduced the effects of formalin in both phases. On the other hand only CE from C. sertularioides induced significant inhibition of the nociceptive response in the first phase. To better assess the potential anti-inflammatory activity of the extracts, the carrageenan-induced peritonitis test was used to test Caulerpa spp. extracts on cell migration into the peritoneal cavity. In this assay, all extracts evaluated were able to significantly inhibit leukocyte migration into the peritoneal cavity in comparison with carrageenan. These data demonstrate that extracts from Caulerpa species elicit pronounced antinociceptive and anti-inflamatory activity against several nociception models. However, pharmacological and chemical studies are continuing in order to characterize the mechanism(s) responsible for the antinociceptive action and also to identify the active principles present in the Caulerpa species. View Full-Text
Keywords: antinociceptive; anti-inflammatory; Caulerpa mexicana; Caulerpa sertularioide; marine algae antinociceptive; anti-inflammatory; Caulerpa mexicana; Caulerpa sertularioide; marine algae
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Brito da Matta, C.B.; De Souza, É.T.; De Queiroz, A.C.; De Lira, D.P.; De Araújo, M.V.; Cavalcante-Silva, L.H.A.; De Miranda, G.E.C.; De Araújo-Júnior, J.X.; Barbosa-Filho, J.M.; De Oliveira Santos, B.V.; Alexandre-Moreira, M.S. Antinociceptive and Anti-Inflammatory Activity from Algae of the Genus Caulerpa. Mar. Drugs 2011, 9, 307-318.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top