Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition
Abstract
:1. Introduction
2. Results and Discussion
2.1. In Vitro DNA Decatenation and Cell Proliferation Assays
2.2. Competitive Inhibition Studies with Neoamphimedine and TopoIIα
2.3. Computational Modeling of Neoamphimedine with TopoIIα
2.4. Discussion
3. Experimental Section
3.1. General Experimental Procedures
3.2. DNA Decatenation Assay
3.3. Cell Proliferation Assay
3.4. Competitive Inhibition Studies
3.5. Molecular Docking of Neoamphimedine and Amphimedine with TopoIIα
4. Conclusions
Acknowledgments
References
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Ponder, J.; Yoo, B.H.; Abraham, A.D.; Li, Q.; Ashley, A.K.; Amerin, C.L.; Zhou, Q.; Reid, B.G.; Reigan, P.; Hromas, R.; et al. Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition. Mar. Drugs 2011, 9, 2397-2408. https://doi.org/10.3390/md9112397
Ponder J, Yoo BH, Abraham AD, Li Q, Ashley AK, Amerin CL, Zhou Q, Reid BG, Reigan P, Hromas R, et al. Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition. Marine Drugs. 2011; 9(11):2397-2408. https://doi.org/10.3390/md9112397
Chicago/Turabian StylePonder, Jessica, Byong Hoon Yoo, Adedoyin D. Abraham, Qun Li, Amanda K. Ashley, Courtney L. Amerin, Qiong Zhou, Brian G. Reid, Philip Reigan, Robert Hromas, and et al. 2011. "Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition" Marine Drugs 9, no. 11: 2397-2408. https://doi.org/10.3390/md9112397
APA StylePonder, J., Yoo, B. H., Abraham, A. D., Li, Q., Ashley, A. K., Amerin, C. L., Zhou, Q., Reid, B. G., Reigan, P., Hromas, R., Nickoloff, J. A., & LaBarbera, D. V. (2011). Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition. Marine Drugs, 9(11), 2397-2408. https://doi.org/10.3390/md9112397