Next Article in Journal
Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp.
Next Article in Special Issue
Search for Hydrophilic Marine Fungal Metabolites: A Rational Approach for Their Production and Extraction in a Bioactivity Screening Context
Previous Article in Journal
Screening and cDNA Cloning of Kv1 Potassium Channel Toxins in Sea Anemones
Previous Article in Special Issue
Verrucisidinol and Verrucosidinol Acetate, Two Pyrone-Type Polyketides Isolated from a Marine Derived Fungus, Penicillium aurantiogriseum
Open AccessReview

Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin

1
Department of Biology, University of Massachusetts Boston, Boston, MA 02125, USA
2
Environmental, Earth and Ocean Sciences Department, University of Massachusetts Boston, Boston, MA 02125, USA
*
Author to whom correspondence should be addressed.
Mar. Drugs 2010, 8(12), 2906-2935; https://doi.org/10.3390/md8122906
Received: 19 October 2010 / Revised: 26 November 2010 / Accepted: 1 December 2010 / Published: 6 December 2010
The amino acid, tyrosine, and its hydroxylated product, 3,4-dihydroxyphenylalanine (dopa), plays an important role in the biogenesis of a number of potentially important bioactive molecules in marine organisms. Interestingly, several of these tyrosyl and dopa‑containing compounds possess dehydro groups in their side chains. Examples span the range from simple dehydrotyrosine and dehydrodopamines to complex metabolic products, including peptides and polycyclic alkaloids. Based on structural information, these compounds can be subdivided into five categories: (a) Simple dehydrotyrosine and dehydrotyramine containing molecules; (b) simple dehydrodopa derivatives; (c) peptidyl dehydrotyrosine and dehydrodopa derivatives; (d) multiple dehydrodopa containing compounds; and (e) polycyclic condensed dehydrodopa derivatives. These molecules possess a wide range of biological activities that include (but are not limited to) antitumor activity, antibiotic activity, cytotoxicity, antioxidant activity, multidrug resistance reversal, cell division inhibition, immunomodulatory activity, HIV-integrase inhibition, anti-viral, and anti-feeding (or feeding deterrent) activity. This review summarizes the structure, distribution, possible biosynthetic origin, and biological activity, of the five categories of dehydrotyrosine and dehydrodopa containing compounds. View Full-Text
Keywords: marine alkaloids; bioactive peptides; dehydrotyrosine; dehydrodopa; dehydrotopa marine alkaloids; bioactive peptides; dehydrotyrosine; dehydrodopa; dehydrotopa
MDPI and ACS Style

Sugumaran, M.; Robinson, W.E. Bioactive Dehydrotyrosyl and Dehydrodopyl Compounds of Marine Origin. Mar. Drugs 2010, 8, 2906-2935.

Show more citation formats Show less citations formats

Article Access Map

1
Only visits after 24 November 2015 are recorded.
Back to TopTop