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Marine Bacterial Sialyltransferases

Glycotechnology Business Unit, Japan Tobacco Inc., 700 Higashibara, Iwata, Shizuoka 438-0802, Japan
Mar. Drugs 2010, 8(11), 2781-2794;
Received: 20 September 2010 / Revised: 25 October 2010 / Accepted: 2 November 2010 / Published: 5 November 2010
(This article belongs to the Special Issue Enzymes from the Sea: Sources, Molecular Biology and Bioprocesses)
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Sialyltransferases transfer N-acetylneuraminic acid (Neu5Ac) from the common donor substrate of these enzymes, cytidine 5’-monophospho-N-acetylneuraminic acid (CMP-Neu5Ac), to acceptor substrates. The enzymatic reaction products including sialyl‑glycoproteins, sialyl-glycolipids and sialyl-oligosaccharides are important molecules in various biological and physiological processes, such as cell-cell recognition, cancer metastasis, and virus infection. Thus, sialyltransferases are thought to be important enzymes in the field of glycobiology. To date, many sialyltransferases and the genes encoding them have been obtained from various sources including mammalian, bacterial and viral sources. During the course of our research, we have detected over 20 bacteria that produce sialyltransferases. Many of the bacteria we isolated from marine environments are classified in the genus Photobacterium or the closely related genus Vibrio. The paper reviews the sialyltransferases obtained mainly from marine bacteria. View Full-Text
Keywords: marine bacteria; Photobacterium; sialyltransferase; sialic acid marine bacteria; Photobacterium; sialyltransferase; sialic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Yamamoto, T. Marine Bacterial Sialyltransferases. Mar. Drugs 2010, 8, 2781-2794.

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