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Open AccessArticle

Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection

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Fitoplancton Tóxico, Instituto de Investigaciones Marinas (CSIC), Eduardo Cabello 6, 36080 Vigo and Instituto Español de Oceanografía, Centro Oceanográfico de Vigo (IEO), Cabo Estay, 36200 Vigo, Spain
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Instituto Universitario de Bio-Orgánica “Antonio González”, Universidad de La Laguna, Astrofísico Francisco Sánchez 2, 38206 La Laguna, Tenerife, Spain
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Departamento de Ingeniería Química y Tecnología Farmacéutica; Universidad de La Laguna; Av. Astrofísico Francisco Sánchez 1, 38071, La Laguna, Tenerife, Spain
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2008, 6(3), 489-495; https://doi.org/10.3390/md6030489
Received: 9 July 2008 / Revised: 10 August 2008 / Accepted: 26 August 2008 / Published: 28 August 2008
Okadaic acid (1) (OA) and its congeners are mainly responsible for diarrhetic shellfish poisoning (DSP) syndrome. The presence of several OA derivatives have already been confirmed in Prorocentrum and Dinophysis spp. In this paper, we report on the detection and identification of a new DSP toxin, the OA isomer 19-epi-okadaic acid (2) (19-epi-OA), isolated from cultures of Prorocentrum belizeanum, by determining its retention time (RT) and fragmentation pattern using liquid chromatography coupled with mass spectrometry (LC–MS/MS). View Full-Text
Keywords: Marine toxins; DSP; 19-epi-okadaic acid; Prorocentrum belizeanum; LC-MS Marine toxins; DSP; 19-epi-okadaic acid; Prorocentrum belizeanum; LC-MS
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Paz, B.; Daranas, A.H.; Cruz, P.G.; Franco, J.M.; Norte, M.; Fernández, J.J. Identification of 19-epi-okadaic Acid, a New Diarrhetic Shellfish Poisoning Toxin, by Liquid Chromatography with Mass Spectrometry Detection. Mar. Drugs 2008, 6, 489-495.

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