Previous Article in Journal
Exploring the Microbial Reservoir of Geodia cydonium (Linnaeus, 1767): Insights into Site-Specific Diversity and Biotechnological Potential
Previous Article in Special Issue
A Comprehensive Review on the Valorization of Bioactives from Marine Animal By-Products for Health-Promoting, Biofunctional Cosmetics
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Marine Drugs
Volume 24
Issue 1
10.3390/md24010003
marinedrugs-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Article

Ly6/uPAR Protein from Asterias rubens Starfish Stimulates Migration and Invasion of Human Epithelial and Immune Cells

by
Ekaterina N. Lyukmanova
1,2,3,4,*,
Tamara Y. Gornostaeva
2,3,
Sergey V. Shabelnikov
5,
Zakhar O. Shenkarev
2,3,
Mikhail P. Kirpichnikov
1,4,
Alexander S. Paramonov
2 and
Maxim L. Bychkov
2
1
Faculty of Biology, Shenzhen MSU-BIT University, Shenzhen 518172, China
2
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow 117997, Russia
3
Moscow Center for Advanced Studies, Moscow 123592, Russia
4
Interdisciplinary Scientific and Educational School of Moscow University «Molecular Technologies of the Living Systems and Synthetic Biology», Faculty of Biology, Lomonosov Moscow State University, Moscow 119234, Russia
5
Institute of Cytology, Russian Academy of Sciences, Tikhoretsky Prospect 4, St. Petersburg 194064, Russia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2026, 24(1), 3; https://doi.org/10.3390/md24010003
Submission received: 10 November 2025 / Revised: 30 November 2025 / Accepted: 16 December 2025 / Published: 19 December 2025
(This article belongs to the Special Issue Marine Bioactives for Functional Cosmetics with Health-Promoting Properties)
Browse Figure
Versions Notes

Abstract

Recently, we found that Lystar5 protein from coelomic cells of A. rubens starfish interacts with nicotinic acetylcholine receptors (nAChRs) and integrin α8-like protein. We hypothesized that Lystar5 mediates detachment of coelomic cells from the matrix and their migration. Skin wound healing in humans is based on keratinocytes migration and is regulated by nAChRs and integrins. Here, we revealed that Lystar5 stimulates migration of human skin HaCaT keratinocytes and peripheral blood monocytes. Using ELISA, we found that Lystar5 binds to the membrane fraction of coelomic cells with its loops I and II, which form an active site of Lystar5 and resemble its pro-migratory activity. In keratinocytes and monocytes, Lystar5 and the peptides mimicking its loops I and II bound with α3, α4, and β2 nAChR and α5, αV, and β1 integrin subunits, which form molecular complexes. In keratinocytes, Lystar5 and its mimetics promoted short-term E/N cadherin switch and upregulated expression of α5 and αV integrins, EGFR, and ICAM-1. In keratinocytes and monocytes, Lystar5 and its mimetics upregulated E-selectin secretion. The ability of Lystar5 and its mimetics to stimulate skin keratinocyte migration and immune cell infiltration may be considered promising for the development of new wound-healing agents.
Keywords: three-finger protein; nicotinic acetylcholine receptor; integrin; E/N cadherin switch; E-selectin; wound healing; Lystar5 three-finger protein; nicotinic acetylcholine receptor; integrin; E/N cadherin switch; E-selectin; wound healing; Lystar5
Graphical Abstract

Share and Cite

MDPI and ACS Style

Lyukmanova, E.N.; Gornostaeva, T.Y.; Shabelnikov, S.V.; Shenkarev, Z.O.; Kirpichnikov, M.P.; Paramonov, A.S.; Bychkov, M.L. Ly6/uPAR Protein from Asterias rubens Starfish Stimulates Migration and Invasion of Human Epithelial and Immune Cells. Mar. Drugs 2026, 24, 3. https://doi.org/10.3390/md24010003

AMA Style

Lyukmanova EN, Gornostaeva TY, Shabelnikov SV, Shenkarev ZO, Kirpichnikov MP, Paramonov AS, Bychkov ML. Ly6/uPAR Protein from Asterias rubens Starfish Stimulates Migration and Invasion of Human Epithelial and Immune Cells. Marine Drugs. 2026; 24(1):3. https://doi.org/10.3390/md24010003

Chicago/Turabian Style

Lyukmanova, Ekaterina N., Tamara Y. Gornostaeva, Sergey V. Shabelnikov, Zakhar O. Shenkarev, Mikhail P. Kirpichnikov, Alexander S. Paramonov, and Maxim L. Bychkov. 2026. "Ly6/uPAR Protein from Asterias rubens Starfish Stimulates Migration and Invasion of Human Epithelial and Immune Cells" Marine Drugs 24, no. 1: 3. https://doi.org/10.3390/md24010003

APA Style

Lyukmanova, E. N., Gornostaeva, T. Y., Shabelnikov, S. V., Shenkarev, Z. O., Kirpichnikov, M. P., Paramonov, A. S., & Bychkov, M. L. (2026). Ly6/uPAR Protein from Asterias rubens Starfish Stimulates Migration and Invasion of Human Epithelial and Immune Cells. Marine Drugs, 24(1), 3. https://doi.org/10.3390/md24010003

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop