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Article

Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts

1
CINBIO, Departamento de Química Inorgánica, Universidade de Vigo, 36310 Vigo, Spain
2
CINBIO, Immunology Group, Universidade de Vigo, 36310 Vigo, Spain
3
Instituto de Investigación Sanitaria Galicia Sur, Hospital Alvaro Cunqueiro, 36312 Vigo, Spain
4
CIM, Universidade de Vigo, 36331 Vigo, Spain
5
Dipartimento Scienze Chimiche, della Vita e della Sostenibilità Ambientale, Università di Parma, 43124 Parma, Italy
6
Institute of Materials for Electronics and Magnetism, National Research Council, 43124 Parma, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Paola Laurienzo
Mar. Drugs 2022, 20(3), 182; https://doi.org/10.3390/md20030182
Received: 24 January 2022 / Revised: 21 February 2022 / Accepted: 24 February 2022 / Published: 28 February 2022
(This article belongs to the Special Issue Nanoparticles from Marine Organisms and Their Biological Activity)
This study reports on the green and cost-efficient synthesis of gold nanoparticles from three different red algae extracts. The nanoparticles synthesized were fully characterized by UV-Vis spectroscopy, HRTEM, and Z-potential. Relevant components occurring in the extracts, such as polysaccharides or phenolic content, were assessed by analytical techniques such as spectrophotometric assays and liquid chromatography. Finally, the antioxidant, antitumoral, and anti-inflammatory potential of both the extracts and the gold nanoparticles synthesized were analyzed in order to determine a possible synergistic effect on the nanoparticles. The results obtained confirmed the obtainment of gold nanoparticles with significant potential as immunotherapeutic agents. The therapeutic potential of these nanoparticles could be higher than that of inert gold nanoparticles loaded with bioactive molecules since the former would allow for higher accumulation into the targeted tissue. View Full-Text
Keywords: green synthesis; Chondrus crispus; Gelidium corneum; Porphyra linearis; gold nanoparticles; antioxidant activity; antitumoral activity; anti-inflammatory activity green synthesis; Chondrus crispus; Gelidium corneum; Porphyra linearis; gold nanoparticles; antioxidant activity; antitumoral activity; anti-inflammatory activity
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MDPI and ACS Style

González-Ballesteros, N.; Diego-González, L.; Lastra-Valdor, M.; Grimaldi, M.; Cavazza, A.; Bigi, F.; Rodríguez-Argüelles, M.C.; Simón-Vázquez, R. Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts. Mar. Drugs 2022, 20, 182. https://doi.org/10.3390/md20030182

AMA Style

González-Ballesteros N, Diego-González L, Lastra-Valdor M, Grimaldi M, Cavazza A, Bigi F, Rodríguez-Argüelles MC, Simón-Vázquez R. Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts. Marine Drugs. 2022; 20(3):182. https://doi.org/10.3390/md20030182

Chicago/Turabian Style

González-Ballesteros, Noelia, Lara Diego-González, Mariano Lastra-Valdor, Maria Grimaldi, Antonella Cavazza, Franca Bigi, M. C. Rodríguez-Argüelles, and Rosana Simón-Vázquez. 2022. "Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts" Marine Drugs 20, no. 3: 182. https://doi.org/10.3390/md20030182

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