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Article

Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252

1
School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
2
Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
*
Authors to whom correspondence should be addressed.
Academic Editors: Susana P. Gaudencio and Florbela Pereira
Mar. Drugs 2021, 19(10), 575; https://doi.org/10.3390/md19100575
Received: 25 September 2021 / Revised: 9 October 2021 / Accepted: 10 October 2021 / Published: 14 October 2021
(This article belongs to the Special Issue Marine Drug Discovery through Computer-Aided Approaches)
Four new anthraquinone derivatives, namely saliniquinones G−I (13) and heraclemycin E (4), were obtained from the Antarctic marine-derived actinomycete Nocardiopsis aegyptia HDN19-252, guided by the Global Natural Products Social (GNPS) molecular networking platform. Their structures, including absolute configurations, were elucidated by extensive NMR, MS, and ECD analyses. Compounds 1 and 2 showed promising inhibitory activity against six tested bacterial strains, including methicillin-resistant coagulase-negative staphylococci (MRCNS), with MIC values ranging from 3.1 to 12.5 μM. View Full-Text
Keywords: anthraquinone derivatives; GNPS; Nocardiopsis aegyptia; MRCNS anthraquinone derivatives; GNPS; Nocardiopsis aegyptia; MRCNS
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MDPI and ACS Style

Zhou, L.; Chen, X.; Sun, C.; Chang, Y.; Huang, X.; Zhu, T.; Zhang, G.; Che, Q.; Li, D. Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252. Mar. Drugs 2021, 19, 575. https://doi.org/10.3390/md19100575

AMA Style

Zhou L, Chen X, Sun C, Chang Y, Huang X, Zhu T, Zhang G, Che Q, Li D. Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252. Marine Drugs. 2021; 19(10):575. https://doi.org/10.3390/md19100575

Chicago/Turabian Style

Zhou, Luning, Xuedong Chen, Chunxiao Sun, Yimin Chang, Xiaofei Huang, Tianjiao Zhu, Guojian Zhang, Qian Che, and Dehai Li. 2021. "Saliniquinone Derivatives, Saliniquinones G−I and Heraclemycin E, from the Marine Animal-Derived Nocardiopsis aegyptia HDN19-252" Marine Drugs 19, no. 10: 575. https://doi.org/10.3390/md19100575

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