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Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-Analysis

Department of Animal Science, Jeonbuk National University, Jeonju 54896, Korea
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Mar. Drugs 2021, 19(1), 26; https://doi.org/10.3390/md19010026
Received: 17 November 2020 / Revised: 18 December 2020 / Accepted: 6 January 2021 / Published: 9 January 2021
This study presents a meta-analysis of studies that investigate the effectiveness of chitosan administration on lifestyle-related disease in murine models. A total of 34 published studies were used to evaluate the effect of chitosan supplementation. The effect sizes for various items after chitosan administration were evaluated using the standardized mean difference. Using Cochran’s Q test, the heterogeneity of effect sizes was assessed, after which a meta-ANOVA and -regression test was conducted to explain the heterogeneity of effect sizes using the mixed-effect model. Publication bias was performed using Egger’s linear regression test. Among the items evaluated, blood triglyceride and HDL-cholesterol showed the highest heterogeneity, respectively. Other than blood HDL-cholesterol, total cholesterol, and triglyceride in feces, most items evaluated showed a negative effect size with high significance in the fixed- and random-effect model (p < 0.0001). In the meta-ANOVA and -regression test, administering chitosan and resistant starch was revealed to be most effective in lowering body weight. In addition, chitosan supplementation proved to be an effective solution for serum TNF-α inhibition. In conclusion, chitosan has been shown to be somewhat useful in improving symptoms of lifestyle-related disease. Although there are some limitations in the results of this meta-analysis due to the limited number of animal experiments conducted, chitosan administration nevertheless shows promise in reducing the risk of cholesterol related metabolic disorder. View Full-Text
Keywords: meta-analysis; chitosan; lifestyle-related disease; cholesterol lowering meta-analysis; chitosan; lifestyle-related disease; cholesterol lowering
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MDPI and ACS Style

Ahn, S.-I.; Cho, S.; Choi, N.-J. Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-Analysis. Mar. Drugs 2021, 19, 26. https://doi.org/10.3390/md19010026

AMA Style

Ahn S-I, Cho S, Choi N-J. Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-Analysis. Marine Drugs. 2021; 19(1):26. https://doi.org/10.3390/md19010026

Chicago/Turabian Style

Ahn, Sung-Il, Sangbuem Cho, and Nag-Jin Choi. 2021. "Effectiveness of Chitosan as a Dietary Supplement in Lowering Cholesterol in Murine Models: A Meta-Analysis" Marine Drugs 19, no. 1: 26. https://doi.org/10.3390/md19010026

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