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Genome-Inspired Chemical Exploration of Marine Fungus Aspergillus fumigatus MF071

1
Griffith Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia
2
Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
3
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2020, 18(7), 352; https://doi.org/10.3390/md18070352
Received: 8 June 2020 / Revised: 30 June 2020 / Accepted: 2 July 2020 / Published: 6 July 2020
The marine-derived fungus Aspergillus fumigatus MF071, isolated from sediment collected from the Bohai Sea, China, yielded two new compounds 19S,20-epoxy-18-oxotryprostatin A (1) and 20-hydroxy-18-oxotryprostatin A (2), in addition to 28 known compounds (330). The chemical structures were established on the basis of 1D, 2D NMR and HRESIMS spectroscopic data. This is the first report on NMR data of monomethylsulochrin-4-sulphate (4) and pseurotin H (10) as naturally occurring compounds. Compounds 15, 16, 20, 23, and 30 displayed weak antibacterial activity (minimum inhibitory concentration: 100 μg/mL). Compounds 18 and 19 exhibited strong activity against S. aureus (minimum inhibitory concentration: 6.25 and 3.13 μg/mL, respectively) and E. coli (minimum inhibitory concentration: 6.25 and 3.13 μg/mL, respectively). A genomic data analysis revealed the putative biosynthetic gene clusters ftm for fumitremorgins, pso for pseurotins, fga for fumigaclavines, and hel for helvolinic acid. These putative biosynthetic gene clusters fundamentally underpinned the enzymatic and mechanistic function study for the biosynthesis of these compounds. The current study reported two new compounds and biosynthetic gene clusters of fumitremorgins, pseurotins, fumigaclavines and helvolinic acid from Aspergillus fumigatus MF071. View Full-Text
Keywords: Aspergillus fumigatus; genome mining; chemical diversity; antimicrobial activity; biosynthetic gene cluster; prenyltransferase Aspergillus fumigatus; genome mining; chemical diversity; antimicrobial activity; biosynthetic gene cluster; prenyltransferase
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Han, J.; Liu, M.; Jenkins, I.D.; Liu, X.; Zhang, L.; Quinn, R.J.; Feng, Y. Genome-Inspired Chemical Exploration of Marine Fungus Aspergillus fumigatus MF071. Mar. Drugs 2020, 18, 352.

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