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Article

Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp.

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Laboratoire de chimie et de biotechnologie des produits naturels, Faculté des Sciences et Technologies, Université de La Réunion, 15 Avenue René Cassin, CS 92003, 97744 Saint-Denis CEDEX 9, La Réunion, France
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Aix-Marseille Univ, CNRS, Centrale Marseille, FSCM, Spectropole, Campus de St Jérôme-Service 511, 13397 Marseille, France
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Naturalis Biodiversity Center, Darwinweg 2, 2333 CR Leiden, The Netherlands
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Institute of Environmental Sciences, Leiden University, Einsteinweg 2, 2333 CC Leiden, The Netherlands
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Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens 15784, Greece
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Crelux GmbH, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany
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Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Sud, Université Paris-Saclay, 1, av. de la Terrasse, 91198 Gif-sur-Yvette, France
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(7), 350; https://doi.org/10.3390/md18070350
Received: 21 May 2020 / Revised: 25 June 2020 / Accepted: 1 July 2020 / Published: 3 July 2020
Chemical study of the CH2Cl2−MeOH (1:1) extract from the sponge Haliclona sp. collected in Mayotte highlighted three new long-chain highly oxygenated polyacetylenes, osirisynes G-I (13) together with the known osirisynes A (4), B (5), and E (6). Their structures were elucidated by 1D and 2D NMR spectra and HRESIMS and MS/MS data. All compounds were evaluated on catalase and sirtuin 1 activation and on CDK7, proteasome, Fyn kinase, tyrosinase, and elastase inhibition. Five compounds (1; 36) inhibited proteasome kinase and two compounds (56) inhibited CDK7 and Fyn kinase. Osirisyne B (5) was the most active compound with IC50 on FYNB kinase, CDK7 kinase, and proteasome inhibition of 18.44 µM, 9.13 µM, and 0.26 µM, respectively. View Full-Text
Keywords: Haliclona sp.; marine sponge; oxygenated polyacetylenes; enzyme inhibitors Haliclona sp.; marine sponge; oxygenated polyacetylenes; enzyme inhibitors
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MDPI and ACS Style

Campos, P.-E.; Herbette, G.; Chendo, C.; Clerc, P.; Tintillier, F.; de Voogd, N.J.; Papanagnou, E.-D.; Trougakos, I.P.; Jerabek, M.; Bignon, J.; Le Goff, G.; Ouazzani, J.; Gauvin-Bialecki, A. Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp. Mar. Drugs 2020, 18, 350. https://doi.org/10.3390/md18070350

AMA Style

Campos P-E, Herbette G, Chendo C, Clerc P, Tintillier F, de Voogd NJ, Papanagnou E-D, Trougakos IP, Jerabek M, Bignon J, Le Goff G, Ouazzani J, Gauvin-Bialecki A. Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp. Marine Drugs. 2020; 18(7):350. https://doi.org/10.3390/md18070350

Chicago/Turabian Style

Campos, Pierre-Eric; Herbette, Gaëtan; Chendo, Christophe; Clerc, Patricia; Tintillier, Florent; de Voogd, Nicole J.; Papanagnou, Eleni-Dimitra; Trougakos, Ioannis P.; Jerabek, Moran; Bignon, Jérôme; Le Goff, Géraldine; Ouazzani, Jamal; Gauvin-Bialecki, Anne. 2020. "Osirisynes G-I, New Long-Chain Highly Oxygenated Polyacetylenes from the Mayotte Marine Sponge Haliclona sp." Mar. Drugs 18, no. 7: 350. https://doi.org/10.3390/md18070350

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