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Open AccessArticle

Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.

Department of Medicinal Molecular Chemistry, Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan
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Mar. Drugs 2020, 18(6), 320; https://doi.org/10.3390/md18060320
Received: 2 June 2020 / Revised: 15 June 2020 / Accepted: 16 June 2020 / Published: 18 June 2020
Halosmysin A, a new 14-membered macrodiolide with an unprecedented skeleton, was isolated from the fungus Halosphaeriaceae sp. OUPS-135D-4, which, in turn, was obtained from the marine algae Sargassum thunbergii. The chemical structure of the macrodiolide was elucidated using 1D and 2D NMR, as well as high resolution fast atom bombardment mass (HRFABMS) spectral analysis. The absolute stereochemistry was determined via chemical derivatization and comparison with a known compound, (6R,11R,12R,14R)-colletodiol. Additionally, halosmysin A was shown to be very potent against murine P388 leukemia, human HL-60 leukemia, and murine L1210 leukemia cell lines, with IC50 values ranging from 2.2 ± 3.1 to 11.7 ± 2.8 μM. View Full-Text
Keywords: macrodiolide; 14-membered ring; Halosphaeriaceae sp.; Sargassum thunbergii; colletodiol; cytotoxicity macrodiolide; 14-membered ring; Halosphaeriaceae sp.; Sargassum thunbergii; colletodiol; cytotoxicity
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Yamada, T.; Kogure, H.; Kataoka, M.; Kikuchi, T.; Hirano, T. Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp.. Mar. Drugs 2020, 18, 320.

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