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Pheophorbide a: State of the Art

Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy
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Mar. Drugs 2020, 18(5), 257; https://doi.org/10.3390/md18050257
Received: 15 April 2020 / Revised: 9 May 2020 / Accepted: 11 May 2020 / Published: 14 May 2020
(This article belongs to the Special Issue Bioactive Compounds Derived from Marine Microalgae 2.0)
Chlorophyll breakdown products are usually studied for their antioxidant and anti-inflammatory activities. The chlorophyll derivative Pheophorbide a (PPBa) is a photosensitizer that can induce significant anti-proliferative effects in several human cancer cell lines. Cancer is a leading cause of death worldwide, accounting for about 9.6 million deaths, in 2018 alone. Hence, it is crucial to monitor emergent compounds that show significant anticancer activity and advance them into clinical trials. In this review, we analyze the anticancer activity of PPBa with or without photodynamic therapy and also conjugated with or without other chemotherapic drugs, highlighting the capacity of PPBa to overcome multidrug resistance. We also report other activities of PPBa and different pathways that it can activate, showing its possible applications for the treatment of human pathologies. View Full-Text
Keywords: microalgae; chlorophyll; anticancer compound; pheophorbide a; cell death microalgae; chlorophyll; anticancer compound; pheophorbide a; cell death
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Saide, A.; Lauritano, C.; Ianora, A. Pheophorbide a: State of the Art. Mar. Drugs 2020, 18, 257.

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