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Diverse Applications of Marine Macroalgae
Open AccessArticle

New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2

1
Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, China
2
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2020, 18(1), 18; https://doi.org/10.3390/md18010018
Received: 19 November 2019 / Revised: 12 December 2019 / Accepted: 22 December 2019 / Published: 24 December 2019
Marine-derived fungi have been reported to have great potential to produce structurally unique metabolites. Our investigation on secondary metabolites from marine-derived fungi resulted in the isolation of seven new polyketides (phomopsiketones D–G (14) and letendronols A–C (57)) as well as one known xylarinol (8) in the cultural broth of Letendraea sp. Their structures and absolute configurations were elucidated using a set of spectroscopic and chemical methods, including HRESIMS, NMR, single-crystal X-ray diffraction, ECD calculation, and a modified version of Mosher’s method. Compound 2 showed weak inhibition against nitric oxide production in lipopolysaccaride-activated macrophages with an IC50 value of 86 μM. View Full-Text
Keywords: marine-derived fungus; Letendraea sp.; polyketide; phomopsiketone; letendronol marine-derived fungus; Letendraea sp.; polyketide; phomopsiketone; letendronol
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MDPI and ACS Style

Xu, Y.; Huang, R.; Liu, H.; Yan, T.; Ding, W.; Jiang, Y.; Wang, P.; Zheng, D.; Xu, J. New Polyketides from the Marine-Derived Fungus Letendraea Sp. 5XNZ4-2. Mar. Drugs 2020, 18, 18.

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