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Open AccessArticle

The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (Gelidium amansii) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters

1
Department of Food Science, National Taiwan Ocean University, Keelung 20224, Taiwan
2
Medical and Pharmaceutical Industry Technology and Development Center, New Taipei City 24886, Taiwan
3
Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan
4
Graduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
5
Department of Pediatrics, College of Medicine, National Taiwan University Hospital, Taipei 10051, Taiwan
6
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(9), 532; https://doi.org/10.3390/md17090532
Received: 21 August 2019 / Revised: 12 September 2019 / Accepted: 12 September 2019 / Published: 13 September 2019
This study investigated the anti-obesity effect of a polysaccharide-rich red algae Gelidium amansii hot-water extract (GHE) in high-fat (HF) diet-induced obese hamsters. GHE contained 68.54% water-soluble indigestible carbohydrate polymers. Hamsters were fed with a HF diet for 5 weeks to induce obesity, and then randomly divided into: HF group, HF with 3% guar gum diet group, HF with 3% GHE diet group, and HF with orlistat (200 mg/kg diet) group for 9 weeks. The increased weights of body, liver, and adipose in the HF group were significantly reversed by GHE supplementation. Lower plasma leptin, tumor necrosis factor-α, and interleukin-6 levels were observed in the GHE+HF group compared to the HF group. GHE also increased the lipolysis rate and decreased the lipoprotein lipase activity in adipose tissues. GHE induced an increase in the phosphorylation of AMP-activated protein kinase (AMPK) and the protein expressions of peroxisome proliferator-activated receptor alpha (PPARα) and uncoupling protein (UCP)-2 in the livers. The decreased triglyceride and total cholesterol in the plasma and liver were also observed in obese hamsters fed a diet with GHE. These results suggest that GHE exerts a down-regulation effect on hepatic lipid metabolism through AMPK phosphorylation and up-regulation of PPARα and UCP-2 in HF-induced obese hamsters. View Full-Text
Keywords: Gelidium amansii hot-water extracts; guar gum; orlistat; obesity; adipocytokines; lipoprotein lipase Gelidium amansii hot-water extracts; guar gum; orlistat; obesity; adipocytokines; lipoprotein lipase
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MDPI and ACS Style

Yang, T.-H.; Chiu, C.-Y.; Lu, T.-J.; Liu, S.-H.; Chiang, M.-T. The Anti-Obesity Effect of Polysaccharide-Rich Red Algae (Gelidium amansii) Hot-Water Extracts in High-Fat Diet-Induced Obese Hamsters. Mar. Drugs 2019, 17, 532.

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