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Open AccessArticle

Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment

1
Laboratories of Marine New Drugs, REDONE Seoul, Seoul 08594, Korea
2
Department of Chemistry and Nanoscience, Ewha Womans University, Seoul 03760, Korea
3
Laboratory of Marine Drugs, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul 08826, Korea
4
College of Pharmacy, Yeungnam University, Gyeongsan-si, Gyeongsangbukdo 38541, Korea
5
Department of Convergence Study on the Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea
6
Research Institute of Oceanography, Seoul National University, NS-80, Seoul 08826, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(7), 422; https://doi.org/10.3390/md17070422
Received: 13 May 2019 / Revised: 17 July 2019 / Accepted: 17 July 2019 / Published: 19 July 2019
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Abstract

Mycousfurans (1 and 2), two new usnic acid congeners, along with (−)-mycousnine (3), (−)-placodiolic acid (4), and (+)-usnic acid (5), were isolated using high-performance liquid chromatography-ultraviolet (HPLC-UV)-guided fractionation of extracts of Mycosphaerella sp. isolated from a marine sediment. The planar structures of 1 and 2 were elucidated using 1D and 2D NMR spectra. The relative configurations of the stereogenic carbons of 1 and 2 were established via analysis of their nuclear Overhauser spectroscopy (NOESY) spectra, and their absolute configurations were determined using a comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1 and 2 were found to have antibacterial activity, showing moderate activity against Kocuria rhizophila and Staphylococcus aureus. View Full-Text
Keywords: usnic acid; mycousfurans; mycousnine; placodiolic acid; Mycosphaerella sp.; antibacterial activity usnic acid; mycousfurans; mycousnine; placodiolic acid; Mycosphaerella sp.; antibacterial activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Lee, J.; Lee, J.; Kim, G.J.; Yang, I.; Wang, W.; Nam, J.-W.; Choi, H.; Nam, S.-J.; Kang, H. Mycousfurans A and B, Antibacterial Usnic Acid Congeners from the Fungus Mycosphaerella sp., Isolated from a Marine Sediment. Mar. Drugs 2019, 17, 422.

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