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Open AccessArticle

Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10

1
Pharmaceutical College, Henan University, Kaifeng 475004, China
2
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, Xiamen 361005, China
3
Eucommia Ulmoides Cultivation and Utilization of Henan Engineering Laboratory, Kaifeng 475004, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Mar. Drugs 2019, 17(6), 332; https://doi.org/10.3390/md17060332
Received: 15 May 2019 / Revised: 29 May 2019 / Accepted: 31 May 2019 / Published: 3 June 2019
Three new butenolide derivatives, namely aspernolides N–P (13), together with six known analogues (49), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 13 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1 and 2 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compound 1 represents the rare example of Aspergillus-derived butenolide derivatives featured by a monosubstituted benzene ring. Compounds 69 exhibited remarkable inhibitory effects against α-glucosidase with IC50 values of 3.87, 1.37, 6.98, and 8.06 μM, respectively, being much more active than the positive control acarbose (190.2 μM). View Full-Text
Keywords: Aspergillus terreus YPGA10; deep-sea-derived fungus; butenolide derivatives; α-glucosidase Aspergillus terreus YPGA10; deep-sea-derived fungus; butenolide derivatives; α-glucosidase
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MDPI and ACS Style

Cheng, Z.; Li, Y.; Liu, W.; Liu, L.; Liu, J.; Yuan, W.; Luo, Z.; Xu, W.; Li, Q. Butenolide Derivatives with α-Glucosidase Inhibitions from the Deep-Sea-Derived Fungus Aspergillus terreus YPGA10. Mar. Drugs 2019, 17, 332.

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