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Open AccessArticle

Anti-Inflammatory and Anti-Aging Evaluation of Pigment–Protein Complex Extracted from Chlorella Pyrenoidosa

by Ruilin Zhang 1,2, Jian Chen 1, Xinwu Mao 3,*, Ping Qi 3 and Xuewu Zhang 1,*
1
College of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
2
Era (China) Company Ltd., Shenzhen 518115; China
3
Guangzhou Institute for Food Inspection, Guangzhou 511400, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 586; https://doi.org/10.3390/md17100586
Received: 10 October 2019 / Revised: 11 October 2019 / Accepted: 14 October 2019 / Published: 16 October 2019
(This article belongs to the Collection Marine Polysaccharides)
Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as “inflamm-aging.” In this study, the potential anti-inflammatory and anti-aging effects of a pigment–protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and D-galactose (D-gal)-induced aging in a murine model. Results indicated that PPC inhibits the production of the inflammatory cytokines TNF-α and IL-6, and the inflammatory mediator nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. It also protected mice from D-gal induced informatory aging by increasing the activity of the antioxidant enzyme, such as superoxide dismutase (SOD), inhibiting D-gal-induced NF-κB upregulation, and increasing PPARs expression in the brain and gut. The findings indicated that PPC has favorable anti-inflammatory and anti-aging properties, and could be useful in the treatment of acute inflammation and senescence diseases. View Full-Text
Keywords: Chlorella pyrenoidosa; pigment–protein complex; anti-inflammation; anti-aging; NF-κB; PPARs Chlorella pyrenoidosa; pigment–protein complex; anti-inflammation; anti-aging; NF-κB; PPARs
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Zhang, R.; Chen, J.; Mao, X.; Qi, P.; Zhang, X. Anti-Inflammatory and Anti-Aging Evaluation of Pigment–Protein Complex Extracted from Chlorella Pyrenoidosa. Mar. Drugs 2019, 17, 586.

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