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Open AccessArticle

Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, Prospect 100-letiya Vladivostoka, 159, Vladivostok 690022, Russia
Department of Marine Biotechnology, Nhatrang Institute of Technology Research and Application, Vietnam Academy of Science and Technology, 650000 Nha Trang, Vietnam
School of Natural Science, Far Eastern Federal University, Sukhanova St., 8, Vladivostok 690000, Russia
Laboratory of Experimental Oncology, Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald-Tumorzentrum, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany
Martini-Klinik Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany
Author to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 579;
Received: 10 September 2019 / Revised: 9 October 2019 / Accepted: 9 October 2019 / Published: 11 October 2019
(This article belongs to the Special Issue Selected Papers from XVI MaNaPro and XI ECMNP)
Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 110 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher’s method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells. View Full-Text
Keywords: marine-derived fungi; secondary metabolites; polyketides; drimanes; meroterpenoids; cytotoxicity marine-derived fungi; secondary metabolites; polyketides; drimanes; meroterpenoids; cytotoxicity
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Yurchenko, A.N.; Trinh, P.T.H.; Girich (Ivanets), E.V.; Smetanina, O.F.; Rasin, A.B.; Popov, R.S.; Dyshlovoy, S.A.; von Amsberg, G.; Menchinskaya, E.S.; Thanh Van, T.T.; Afiyatullov, S.S. Biologically Active Metabolites from the Marine Sediment-Derived Fungus Aspergillus flocculosus. Mar. Drugs 2019, 17, 579.

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