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A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance

Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Cairo 11566, Egypt
Department of Pharmaceutical Sciences, Pharmacy Program, Batterjee Medical College, North Obhur, P.O. Box 6231, Jeddah 21442, Saudi Arabia
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 559;
Received: 28 August 2019 / Revised: 26 September 2019 / Accepted: 28 September 2019 / Published: 29 September 2019
Fungal marine microorganisms are a valuable source of bioactive natural products. Fungal secondary metabolites mainly comprise alkaloids, terpenoids, peptides, polyketides, steroids, and lactones. Proteins and peptides from marine fungi show minimal human toxicity and less adverse effects comparable to synthetic drugs. This review summarizes the chemistry and the biological activities of peptides that were isolated and structurally elucidated from marine fungi. Relevant fungal genera including Acremonium, Ascotricha, Aspergillus, Asteromyces, Ceratodictyon, Clonostachys, Emericella, Exserohilum, Microsporum, Metarrhizium, Penicillium, Scytalidium, Simplicillium, Stachylidium, Talaromyces, Trichoderma, as well as Zygosporium were extensively reviewed. About 131 peptides were reported from these 17 genera and their structures were unambiguously determined using 1D and 2D NMR (one and two dimensional nuclear magnetic resonance) techniques in addition to HRMS (high resolution mass spectrometry). Marfey and Mosher reactions were used to confirm the identity of these compounds. About 53% of the isolated peptides exhibited cytotoxic, antimicrobial, and antiviral activity, meanwhile, few of them showed antidiabetic, lipid lowering, and anti-inflammatory activity. However 47% of the isolated peptides showed no activity with respect to the examined biological activity and thus required further in depth biological assessment. In conclusion, when searching for bioactive natural products, it is worth exploring more peptides of fungal origin and assessing their biological activities. View Full-Text
Keywords: biological activity; chemistry; marine derived fungi; peptides biological activity; chemistry; marine derived fungi; peptides
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MDPI and ACS Style

Youssef, F.S.; Ashour, M.L.; Singab, A.N.B.; Wink, M. A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance. Mar. Drugs 2019, 17, 559.

AMA Style

Youssef FS, Ashour ML, Singab ANB, Wink M. A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance. Marine Drugs. 2019; 17(10):559.

Chicago/Turabian Style

Youssef, Fadia S., Mohamed L. Ashour, Abdel N.B. Singab, and Michael Wink. 2019. "A Comprehensive Review of Bioactive Peptides from Marine Fungi and Their Biological Significance" Marine Drugs 17, no. 10: 559.

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