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Cytotoxic and Antiproliferative Effects of Preussin, a Hydroxypyrrolidine Derivative from the Marine Sponge-Associated Fungus Aspergillus candidus KUFA 0062, in a Panel of Breast Cancer Cell Lines and Using 2D and 3D Cultures
Open AccessArticle

Asperienes A–D, Bioactive Sesquiterpenes from the Marine-Derived Fungus Aspergillus flavus

1
Key Laboratory of Medicinal Chemistry and Molecular Diagnostics of Education Ministry of China, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China
2
College of Life Sciences, Hebei University, Baoding 071002, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 550; https://doi.org/10.3390/md17100550
Received: 4 August 2019 / Revised: 24 September 2019 / Accepted: 24 September 2019 / Published: 26 September 2019
Marine-derived fungi of the genera Aspergillus could produce novel compounds with significant bioactivities. Among these fungi, the strain Aspergillus flavus is notorious for its mutagenic mycotoxins production. However, some minor components with certain toxicities from A. flavus have not been specifically surveyed and might have potent biological activities. Our investigation of the marine-derived fungus Aspergillus flavus CF13-11 cultured in solid medium led to the isolation of four C-6′/C-7′ epimeric drimane sesquiterpene esters, asperienes A–D (14). Their absolute configurations were assigned by electronic circular dichroism (ECD) and Snatzke’s methods. This is the first time that two pairs of C-6′/C-7′ epimeric drimane sesquiterpene esters have successfully been separated. Aperienes A–D (14) displayed potent bioactivities towards four cell lines with the IC50 values ranging from 1.4 to 8.3 μM. Interestingly, compounds 1 and 4 exhibited lower toxicities than 2 and 3 toward normal GES-1 cells, indicating more potential for development as an antitumor agent in the future. View Full-Text
Keywords: marine-derived fungus; Aspergillus flavus; sesquiterpene; bioactivity marine-derived fungus; Aspergillus flavus; sesquiterpene; bioactivity
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MDPI and ACS Style

Liu, Y.-F.; Yue, Y.-F.; Feng, L.-X.; Zhu, H.-J.; Cao, F. Asperienes A–D, Bioactive Sesquiterpenes from the Marine-Derived Fungus Aspergillus flavus. Mar. Drugs 2019, 17, 550.

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