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Open AccessArticle

The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice

1
College of Chemical Engineering, Huaqiao University, Xiamen 361021, China
2
Xiamen Engineering and Technological Research Center for Comprehensive Utilization of Marine Biological Resources, Xiamen 361021, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2019, 17(10), 541; https://doi.org/10.3390/md17100541
Received: 18 August 2019 / Revised: 10 September 2019 / Accepted: 16 September 2019 / Published: 20 September 2019
Type 2 diabetes mellitus (T2DM) accounts for more than 90% of cases of diabetes mellitus, which is harmful to human health. Herein, neoagaro-oligosaccharides (NAOs) were prepared and their potential as a treatment of T2DM was evaluated in KunMing (KM) mice. Specifically, a T2DM mice model was established by the combination of a high-fat diet (HFD) and alloxan injection. Consequently, the mice were given different doses of NAOs (100, 200, or 400 mg/kg) and the differences among groups of mice were recorded. As a result of the NAOs treatment, the fasting blood glucose (FBG) was lowered and the glucose tolerance was improved as compared with the model group. As indicated by the immunohistochemistry assay, the NAOs treatment was able to ameliorate hepatic macrovesicular steatosis and hepatocyte swelling, while it also recovered the number of pancreatic β-cells. Additionally, NAOs administration benefited the antioxidative capacity in mice as evidenced by the upregulation of both glutathione peroxidase and superoxide dismutase activity and the significant reduction of the malondialdehyde concentration. Furthermore, NAOs, as presented by Western blotting, increased the expression of p-ERK1/2, p-JNK, NQO1, HO-1, and PPARγ, via the MAPK, Nrf2, and PPARγ signaling pathways, respectively. In conclusion, NAOs can be used to treat some complications caused by T2DM, and are beneficial in controlling the level of blood glucose and ameliorating the damage of the liver and pancreatic islands. View Full-Text
Keywords: type 2 diabetes mellitus; neoagaro-oligosaccharides; MAPK; Nrf2; PPARγ type 2 diabetes mellitus; neoagaro-oligosaccharides; MAPK; Nrf2; PPARγ
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MDPI and ACS Style

Lin, F.; Yang, D.; Huang, Y.; Zhao, Y.; Ye, J.; Xiao, M. The Potential of Neoagaro-Oligosaccharides as a Treatment of Type II Diabetes in Mice. Mar. Drugs 2019, 17, 541.

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