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Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin

1
The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China
2
Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300350, China
*
Authors to whom correspondence should be addressed.
Mar. Drugs 2018, 16(9), 338; https://doi.org/10.3390/md16090338
Received: 28 August 2018 / Revised: 7 September 2018 / Accepted: 12 September 2018 / Published: 17 September 2018
The first total synthesis of carmabin A and dragomabin was achieved at 52.3 mg and 43.8 mg scale, respectively. The synthesis led to determination of the configuration of carmabin A and reassignment of the configuration of dragomabin at the stereogenic centre on the alkyne-bearing fragment. View Full-Text
Keywords: total synthesis; stereochemical determination/revision; carmabin A; dragomabin total synthesis; stereochemical determination/revision; carmabin A; dragomabin
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Ye, B.; Jiang, P.; Zhang, T.; Sun, Y.; Hao, X.; Cui, Y.; Wang, L.; Chen, Y. Total Synthesis of the Highly N-Methylated Peptides Carmabin A and Dragomabin. Mar. Drugs 2018, 16, 338.

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