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Mar. Drugs 2018, 16(9), 337;

Isolation, Characterization, and Pharmaceutical Applications of an Exopolysaccharide from Aerococcus Uriaeequi

State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China
Qingdao Municipal Center for Disease Control & Prevention, Qingdao 266033, China
Qingdao Institute of Preventive Medicine, Qingdao 266033, China
Author to whom correspondence should be addressed.
Received: 28 August 2018 / Revised: 13 September 2018 / Accepted: 13 September 2018 / Published: 16 September 2018
(This article belongs to the Collection Marine Polysaccharides)
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Many marine bacteria secrete exopolysaccharides (EPSs), which are made up of a substantial component of the macro-molecules surrounding cells. Recently, the wide demand for EPSs for food, cosmetics, pharmaceutical and other applications has led to great interest in them. In this study, an EPS produced by marine bacteria Aerococcus uriaeequi HZ strains (EPS-A) was isolated and purified to examine its structure and biological function. The molecular weight of EPS-A analyzed by high-performance liquid gel filtration chromatography (HPGFC) is found to have a number average of 2.22 × 105 and weight average of 2.84 × 105, respectively. High-performance liquid chromatography (HPLC) and Fourier-transform–infrared (FT–IR) analysis indicate that EPS-A was a polysaccharide composed of glucose and a little mannose. In addition, the flocculating rate of sewage of EPS-A was 79.90%. The hygroscopicity studies showed that hygroscopicity of EPS-A was higher than chitosan but lower than that of sodium hyaluronate. The moisture retention of EPS-A showed similar retention activity to both chitosan and sodium hyaluronate. EPS-A also can scavenge free radicals including both OH• free radical and O2 free radical and the activity to O2 free radical is similar to vitamin C. Safety assessment on mice indicated that the EPS-A is safe for external use and oral administration. EPS-A has great potential for applications in medicine due to its characteristics mentioned above. View Full-Text
Keywords: marine bacteria; EPS-A; structural analysis; sewage flocculation; oxidation resistance marine bacteria; EPS-A; structural analysis; sewage flocculation; oxidation resistance

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Wang, C.; Fan, Q.; Zhang, X.; Lu, X.; Xu, Y.; Zhu, W.; Zhang, J.; Hao, W.; Hao, L. Isolation, Characterization, and Pharmaceutical Applications of an Exopolysaccharide from Aerococcus Uriaeequi. Mar. Drugs 2018, 16, 337.

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