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Mar. Drugs 2018, 16(4), 136; https://doi.org/10.3390/md16040136

Eurotiumins A–E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452

1
CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China
2
University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
3
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
4
State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, 100 Central Xianlie Road, Guangzhou 510070, China
*
Authors to whom correspondence should be addressed.
Received: 25 March 2018 / Revised: 14 April 2018 / Accepted: 18 April 2018 / Published: 21 April 2018
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Abstract

Three new prenylated indole 2,5-diketopiperazine alkaloids (13) with nine known ones (513), one new indole alkaloid (4), and one new bis-benzyl pyrimidine derivative (14) were isolated and characterized from the marine-derived fungus Eurotium sp. SCSIO F452. 1 and 2, occurring as a pair of diastereomers, both presented a hexahydropyrrolo[2,3-b]indole skeleton. Their chemical structures, including absolute configurations, were elucidated by 1D and 2D NMR, HRESIMS, quantum chemical calculations of electronic circular dichroism, and single crystal X-ray diffraction experiments. Most isolated compounds were screened for antioxidative potency. Compounds 3, 5, 6, 7, 9, 10, and 12 showed significant radical scavenging activities against DPPH with IC50 values of 13, 19, 4, 3, 24, 13, and 18 µM, respectively. Five new compounds were evaluated for cytotoxic activities. View Full-Text
Keywords: prenylated indole alkaloid; benzyl pyrimidine; antioxidative and cytotoxic activities; marine fungi prenylated indole alkaloid; benzyl pyrimidine; antioxidative and cytotoxic activities; marine fungi
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Zhong, W.-M.; Wang, J.-F.; Shi, X.-F.; Wei, X.-Y.; Chen, Y.-C.; Zeng, Q.; Xiang, Y.; Chen, X.-Y.; Tian, X.-P.; Xiao, Z.-H.; Zhang, W.-M.; Wang, F.-Z.; Zhang, S. Eurotiumins A–E, Five New Alkaloids from the Marine-Derived Fungus Eurotium sp. SCSIO F452. Mar. Drugs 2018, 16, 136.

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