Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8
1
Department of Organic Material Science and Engineering, Pusan National University, Busan 46241, Korea
2
Marine Biotechnology Center for Pharmaceuticals and Foods, Silla University, Busan 46958, Korea
3
Department of Food and Nutrition, College of Medical and Life Sciences, Silla University, Busan 46958, Korea
4
Food Safety and Processing Research Division, National Institute of Fisheries Science, Busan 46083, Korea
5
Division of Marine Bioscience, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 49112, Korea
6
Department of Convergence Study on the Ocean Science and Technology, Ocean Science and Technology School, Korea Maritime and Ocean University, Busan 49112, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Mar. Drugs 2016, 14(9), 168; https://doi.org/10.3390/md14090168
Received: 9 June 2016 / Revised: 1 September 2016 / Accepted: 7 September 2016 / Published: 14 September 2016
(This article belongs to the Special Issue Marine Natural Products that Target Metabolic Disorders)
Lack of bone formation-related health problems are a major problem for the aging population in the modern world. As a part of the ongoing trend of developing natural substances that attenuate osteoporotic bone loss conditions, dioxinodehydroeckol (DHE) from edible brown alga Ecklonia cava was tested for its effects on osteoblastogenic differentiation in MC3T3-E1 pre-osteoblasts. DHE was observed to successfully enhance osteoblast differentiation, as indicated by elevated cell proliferation, alkaline phosphatase activity, intracellular cell mineralization, along with raised levels of osteoblastogenesis indicators at the concentration of 20 μM. Results suggested a possible intervening of DHE on the bone morphogenetic protein (BMP) signaling pathway, according to elevated protein levels of BMP-2, collagen-I, and Smads. In addition, the presence of DHE was also able to raise the phosphorylated extracellular signal–regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) levels which are also activated by the BMP signaling pathway. In conclusion, DHE is suggested to be a potential bioactive compound against bone loss that could enhance osteoblastogenesis with a suggested BMP pathway interaction.
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Keywords:
BMP-2; dioxinodehydroeckol; Ecklonia cava; osteoblastogenesis; Smad
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MDPI and ACS Style
Ahn, B.-N.; Karadeniz, F.; Kong, C.-S.; Nam, K.-H.; Jang, M.-S.; Seo, Y.; Kim, H.S. Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8. Mar. Drugs 2016, 14, 168.
AMA Style
Ahn B-N, Karadeniz F, Kong C-S, Nam K-H, Jang M-S, Seo Y, Kim HS. Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8. Marine Drugs. 2016; 14(9):168.
Chicago/Turabian StyleAhn, Byul-Nim; Karadeniz, Fatih; Kong, Chang-Suk; Nam, Ki-Ho; Jang, Mi-Soon; Seo, Youngwan; Kim, Han S. 2016. "Dioxinodehydroeckol Enhances the Differentiation of Osteoblasts by Regulating the Expression of Phospho-Smad1/5/8" Mar. Drugs 14, no. 9: 168.
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