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Open AccessArticle

Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Laboratory for Marin Drugs and Bioproducts, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Orazio Taglialatela-Scafati
Mar. Drugs 2016, 14(7), 131;
Received: 8 June 2016 / Revised: 5 July 2016 / Accepted: 5 July 2016 / Published: 14 July 2016
PDF [2261 KB, uploaded 14 July 2016]


Three new meroterpenoids, named austalides S-U (13), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (414). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, and TDDFT ECD calculations. Compound 1 is the first case of austalides with the terpene ring fused to the chroman ring in trans configuration. Compounds 3 and 5 exhibited activities against influenza virus A (H1N1), with IC50 values of 90 and 99 μM, respectively. View Full-Text
Keywords: austalide; fungus; influenza virus A austalide; fungus; influenza virus A

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Peng, J.; Zhang, X.; Wang, W.; Zhu, T.; Gu, Q.; Li, D. Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107. Mar. Drugs 2016, 14, 131.

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