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Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug

Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, and IBIMA (Biomedical Research Institute of Málaga), Universidad de Málaga, Andalucía Tech, Málaga 29071, Spain
CIBER de Enfermedades Raras (CIBERER), Málaga E-29071, Spain
Author to whom correspondence should be addressed.
Present address: Departamento de Desarrollo y Reparación Cardiovascular, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid 28029, Spain.
Academic Editor: Keith B. Glaser
Mar. Drugs 2016, 14(1), 1;
Received: 13 October 2015 / Revised: 7 December 2015 / Accepted: 16 December 2015 / Published: 22 December 2015
PDF [1124 KB, uploaded 22 December 2015]


Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological activities potentially beneficial to human health. (+)-Aeroplysinin-1 is a secondary metabolite isolated from marine sponges with a wide spectrum of bio-activities. (+)-Aeroplysinin-1 has potent antibiotic effects on Gram-positive bacteria and several dinoflagellate microalgae causing toxic blooms. In preclinical studies, (+)-aeroplysinin-1 has been shown to have promising anti-inflammatory, anti-angiogenic and anti-tumor effects. Due to its versatility, (+)-aeroplysinin-1 might have a pharmaceutical interest for the treatment of different pathologies. View Full-Text
Keywords: (+)-aeroplysinin-1; sponges; marine drugs; inflammation; angiogenesis; cancer (+)-aeroplysinin-1; sponges; marine drugs; inflammation; angiogenesis; cancer

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García-Vilas, J.A.; Martínez-Poveda, B.; Quesada, A.R.; Medina, M.Á. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug. Mar. Drugs 2016, 14, 1.

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