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Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.

Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea
Author to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Mar. Drugs 2015, 13(8), 5187-5200;
Received: 29 June 2015 / Revised: 28 July 2015 / Accepted: 30 July 2015 / Published: 14 August 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
PDF [336 KB, uploaded 14 August 2015]


Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and b-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria. View Full-Text
Keywords: marine actinomycete; secondary metabolite; hormaomycin; peptide; antibiotic marine actinomycete; secondary metabolite; hormaomycin; peptide; antibiotic

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Bae, M.; Chung, B.; Oh, K.-B.; Shin, J.; Oh, D.-C. Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.. Mar. Drugs 2015, 13, 5187-5200.

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