Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
1
Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
2
Department of Agricultural Biotechnology, College of Agriculture and Life Science, Seoul National University, Seoul 151-921, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Valeria Costantino
Mar. Drugs 2015, 13(8), 5187-5200; https://doi.org/10.3390/md13085187
Received: 29 June 2015 / Revised: 28 July 2015 / Accepted: 30 July 2015 / Published: 14 August 2015
(This article belongs to the Special Issue Marine Secondary Metabolites)
Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and b-methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria.
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Keywords:
marine actinomycete; secondary metabolite; hormaomycin; peptide; antibiotic
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MDPI and ACS Style
Bae, M.; Chung, B.; Oh, K.-B.; Shin, J.; Oh, D.-C. Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.. Mar. Drugs 2015, 13, 5187-5200.
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