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Mar. Drugs 2015, 13(8), 4721-4732;

Nrf2 and NF-κB Signaling Pathways Contribute to Porphyra-334-Mediated Inhibition of UVA-Induced Inflammation in Skin Fibroblasts

Department of Food and Life Science, Pukyong National University, Busan 608-737, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Peer B. Jacobson
Received: 15 June 2015 / Revised: 8 July 2015 / Accepted: 22 July 2015 / Published: 31 July 2015
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In this study, we examined the protective effects of porphyra-334 against UVA-irradiated cellular damage and elucidated the underlying mechanisms. Porphyra-334 prevented UVA-induced cell death and exhibited scavenging activities against intracellular oxidative stress induced by UVA irradiation in skin fibroblasts. We found that porphyra-334 significantly reduced the secretion and expression of IL-6 and TNF-α, reduced nuclear expression of Nuclear factor-κB (NF-κB), and sustained NF-E2-related factor 2 (Nrf2) activation. Further mechanism research revealed that porphyra-334 promoted the Nrf2 signaling pathway in UVA-irradiated skin fibroblasts. Our results show that the antioxidant effect of porphyra-334 is due to the direct scavenging of oxidative stress and its inhibitory effects on NF-κB-dependent inflammatory genes, such as IL-6 and TNF-κ. Therefore, we hypothesize that boosting the Nrf2- NF-κB-dependent response to counteract environmental stress is a promising strategy for the prevention of UVA-related damage. View Full-Text
Keywords: porphyra-334; Nrf-2; NF-κB; oxidative stress porphyra-334; Nrf-2; NF-κB; oxidative stress

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Ryu, J.; Kwon, M.-J.; Nam, T.-J. Nrf2 and NF-κB Signaling Pathways Contribute to Porphyra-334-Mediated Inhibition of UVA-Induced Inflammation in Skin Fibroblasts. Mar. Drugs 2015, 13, 4721-4732.

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