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Open AccessArticle

New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis

Fundación MEDINA, Centro de Excelencia en Investigación de Medicamentos Innovadores en Andalucía, Avda. del Conocimiento 34, Armilla, Granada 18016, Spain
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Academic Editor: Kirk R. Gustafson
Mar. Drugs 2015, 13(1), 128-140; https://doi.org/10.3390/md13010128
Received: 13 November 2014 / Accepted: 16 December 2014 / Published: 29 December 2014
(This article belongs to the Special Issue Bioactive Compounds from Marine Microbes)
A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (13) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolite ikarugamycin (4). Their structural elucidation was accomplished using a combination of electrospray-time of flight mass spectrometry (ESI-TOF MS) and 1D and 2D NMR analyses. Compounds 13 showed antifungal activity against Aspergillus fumigatus, Candida albicans and antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). View Full-Text
Keywords: Streptomyces zhaozhouensis; ikarugamycin; polycyclic tetramate macrolactams; antifungal; antibacterial Streptomyces zhaozhouensis; ikarugamycin; polycyclic tetramate macrolactams; antifungal; antibacterial
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Lacret, R.; Oves-Costales, D.; Gómez, C.; Díaz, C.; De la Cruz, M.; Pérez-Victoria, I.; Vicente, F.; Genilloud, O.; Reyes, F. New Ikarugamycin Derivatives with Antifungal and Antibacterial Properties from Streptomyces zhaozhouensis. Mar. Drugs 2015, 13, 128-140.

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