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The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

1,3,4, 2, 1,*, 1,3,4 and 1
Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China
School of Life Sciences, Nantong University, Seyuan Road 9, Nantong 226019, China
Nantong Branch, Institute of Oceanology, Chinese Academy of Sciences, Nantong, Jiangsu 226006, China
Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, Qingdao 266071, China
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(6), 3292-3306;
Received: 18 February 2014 / Revised: 9 May 2014 / Accepted: 9 May 2014 / Published: 30 May 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
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Diabetic nephropathy (DN) has long been recognized as the leading cause of end-stage renal disease, but the efficacy of available strategies for the prevention of DN remains poor. The aim of this study was to investigate the possible beneficial effects of fucoidan (FPS) in streptozotocin (STZ)-induced diabetes in rats. Wistar rats were made diabetic by injection of STZ after removal of the right kidney. FPS was administered to these diabetic rats for 10 weeks. Body weight, physical activity, renal function, and renal morphometry were measured after 10 weeks of treatment. In the FPS-treated group, the levels of blood glucose, BUN, Ccr and Ucr decreased significantly, and microalbumin, serum insulin and the β2-MG content increased significantly. Moreover, the FPS-treated group showed improvements in renal morphometry. In summary, FPS can ameliorate the metabolic abnormalities of diabetic rats and delay the progression of diabetic renal complications. View Full-Text
Keywords: sulfated polysaccharide; fucoidan; diabetic nephropathy sulfated polysaccharide; fucoidan; diabetic nephropathy

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Wang, J.; Liu, H.; Li, N.; Zhang, Q.; Zhang, H. The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy. Mar. Drugs 2014, 12, 3292-3306.

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