Next Article in Journal
Gram-Negative Marine Bacteria: Structural Features of Lipopolysaccharides and Their Relevance for Economically Important Diseases
Next Article in Special Issue
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases
Previous Article in Journal
Marinopyrrole Derivatives as Potential Antibiotic Agents against Methicillin-Resistant Staphylococcus aureus (III)
Previous Article in Special Issue
Development of Pedigree Classification Using Microsatellite and Mitochondrial Markers for Giant Grouper Broodstock (Epinephelus lanceolatus) Management in Taiwan
Article

Antiplatelet and Anticoagulant Effects of Diterpenes Isolated from the Marine Alga, Dictyota menstrualis

1
Departamento de Biologia Molecular e Celular, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista, s/n, Centro, Niterói, 24020-141, RJ, Brazil
2
Departamento de Biologia Marinha, Instituto de Biologia, Universidade Federal Fluminense, Outeiro de São João Batista, s/n, Centro, Niterói, 24001-970, RJ, Brazil
*
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(5), 2471-2484; https://doi.org/10.3390/md12052471
Received: 12 December 2013 / Revised: 1 April 2014 / Accepted: 3 April 2014 / Published: 30 April 2014
(This article belongs to the Special Issue Advances and New Perspectives in Marine Biotechnology)
Cardiovascular diseases represent a major cause of disability and death worldwide. Therapeutics are available, but they often have unsatisfactory results and may produce side effects. Alternative treatments based on the use of natural products have been extensively investigated, because of their low toxicity and side effects. Marine organisms are prime candidates for such products, as they are sources of numerous and complex substances with ecological and pharmacological effects. In this work, we investigated, through in vitro experiments, the effects of three diterpenes (pachydictyol A, isopachydictyol A and dichotomanol) from the Brazilian marine alga, Dictyota menstrualis, on platelet aggregation and plasma coagulation. Results showed that dichotomanol inhibited ADP- or collagen-induced aggregation of platelet-rich plasma (PRP), but failed to inhibit washed platelets (WP). In contrast, pachydictyol A and isopachydictyol A failed to inhibit the aggregation of PRP, but inhibited WP aggregation induced by collagen or thrombin. These diterpenes also inhibited coagulation analyzed by the prothrombin time and activated partial thromboplastin time and on commercial fibrinogen. Moreover, diterpenes inhibited the catalytic activity of thrombin. Theoretical studies using the Osiris Property Explorer software showed that diterpenes have low theoretical toxicity profiles and a drug-score similar to commercial anticoagulant drugs. In conclusion, these diterpenes are promising candidates for use in anticoagulant therapy, and this study also highlights the biotechnological potential of oceans and the importance of bioprospecting to develop medicines. View Full-Text
Keywords: anticoagulant effect; antiplatelet activity; brown algae; Dictyota menstrualis; diterpenes anticoagulant effect; antiplatelet activity; brown algae; Dictyota menstrualis; diterpenes
Show Figures

Figure 1

MDPI and ACS Style

De Andrade Moura, L.; Marqui de Almeida, A.C.; Domingos, T.F.S.; Ortiz-Ramirez, F.; Cavalcanti, D.N.; Teixeira, V.L.; Fuly, A.L. Antiplatelet and Anticoagulant Effects of Diterpenes Isolated from the Marine Alga, Dictyota menstrualis. Mar. Drugs 2014, 12, 2471-2484. https://doi.org/10.3390/md12052471

AMA Style

De Andrade Moura L, Marqui de Almeida AC, Domingos TFS, Ortiz-Ramirez F, Cavalcanti DN, Teixeira VL, Fuly AL. Antiplatelet and Anticoagulant Effects of Diterpenes Isolated from the Marine Alga, Dictyota menstrualis. Marine Drugs. 2014; 12(5):2471-2484. https://doi.org/10.3390/md12052471

Chicago/Turabian Style

De Andrade Moura, Laura, Ana C. Marqui de Almeida, Thaisa F.S. Domingos, Fredy Ortiz-Ramirez, Diana N. Cavalcanti, Valéria L. Teixeira, and André L. Fuly 2014. "Antiplatelet and Anticoagulant Effects of Diterpenes Isolated from the Marine Alga, Dictyota menstrualis" Marine Drugs 12, no. 5: 2471-2484. https://doi.org/10.3390/md12052471

Find Other Styles

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop