Mar. Drugs 2014, 12(4), 1977-1986; https://doi.org/10.3390/md12041977
New Terpenes from the Egyptian Soft Coral Sarcophyton ehrenbergi
Ahmed Elkhateeb 1, Ahmed A. El-Beih 2, Amira M. Gamal-Eldeen 3, Montaser A. Alhammady 4, Shinji Ohta 5, Paul W. Paré 6
and Mohamed-Elamir F. Hegazy 7,*
and Mohamed-Elamir F. Hegazy 7,*
1
Phytochemistry and Plant Systematic Department, National Research Centre, El-Tahrir St., Dokki, Giza 12311, Egypt
2
Department of Chemistry of Natural & Microbial Products and Center of Excellence Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12311, Egypt
3
Cancer Biology Lab, Center of Excellence for Advanced Sciences & Biochemistry Department, National Research Center, Dokki, Cairo 12311, Egypt
4
National Institute of Oceanography and Fisheries, Red Sea Branch, Hurghada 84511, Egypt
5
Graduate School of Biosphere Science, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-852, Japan
6
Department of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA
7
Chemistry of Medicinal Plants Department and Center of Excellence Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12311, Egypt
*
Author to whom correspondence should be addressed.
Received: 31 December 2013 / Revised: 11 March 2014 / Accepted: 14 March 2014 / Published: 2 April 2014
Abstract
Chemical investigations of the Egyptian soft coral Sarcophyton ehrenbergi have led to the isolation of compounds 1–3 as well as the previously reported marine cembranoid diterpene sarcophine (4). Structures were elucidated by comprehensive NMR and HRMS experimentation. Isolated compounds were in vitro assayed for cytotoxic activity against human hepatocarcinoma (HepG2) and breast adenocarcinoma (MCF-7) cell lines. View Full-TextKeywords:
Sarcophyton ehrenbergi; soft coral; terpenes; cembranoids; sesquiterpenes; cytotoxic activity
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Elkhateeb, A.; El-Beih, A.A.; Gamal-Eldeen, A.M.; Alhammady, M.A.; Ohta, S.; Paré, P.W.; Hegazy, M.-E.F. New Terpenes from the Egyptian Soft Coral Sarcophyton ehrenbergi. Mar. Drugs 2014, 12, 1977-1986.
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