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Mar. Drugs 2014, 12(12), 6213-6235;

An Update on 2,5-Diketopiperazines from Marine Organisms

Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530001, China
Department of Cell Biology, Jinan University, Guangzhou 510632, China
Life Science & Technology School, Lingnan Normal University, Zhanjiang 52048, China
Key Laboratory of Marine Environmental Science, Guangxi Academy of Sciences, Nanning 530007, China
Author to whom correspondence should be addressed.
Received: 14 September 2014 / Revised: 5 December 2014 / Accepted: 9 December 2014 / Published: 19 December 2014
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2,5-Diketopiperazines (2,5-DKPs) are an important category of structurally diverse cyclic dipeptides with prominent biological properties. These 2,5-DKPs have been obtained from a variety of natural resources, including marine organisms. Because of the increasing numbers and biological importance of these compounds, this review covers 90 marine originated 2,5-DKPs that were reported from 2009 to the first half-year of 2014. The review will focus on the structure characterizations, biological properties and proposed biosynthetic processes of these compounds. View Full-Text
Keywords: 2,5-diketopiperazine; marine organism; biosynthetic processes; biological activity 2,5-diketopiperazine; marine organism; biosynthetic processes; biological activity

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Huang, R.-M.; Yi, X.-X.; Zhou, Y.; Su, X.; Peng, Y.; Gao, C.-H. An Update on 2,5-Diketopiperazines from Marine Organisms. Mar. Drugs 2014, 12, 6213-6235.

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