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Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.

1
Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
3
Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou 510060, China
4
Jilin Provincial Academy of Chinese Medicine Sciences, Changchun 130021, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(10), 5316-5327; https://doi.org/10.3390/md12105316
Received: 6 August 2014 / Revised: 7 October 2014 / Accepted: 8 October 2014 / Published: 23 October 2014
Eight new compounds, sinulolides A–H (18), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were determined on the basis of electronic circular dichroism (ECD) data analysis. Compounds 5 and 10 exhibited moderate effects for the inhibition of NF-κB activation. View Full-Text
Keywords: soft coral; Sinularia sp.; sinulolide; NF-κB soft coral; Sinularia sp.; sinulolide; NF-κB
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Yang, B.; Wei, X.; Huang, J.; Lin, X.; Liu, J.; Liao, S.; Wang, J.; Zhou, X.; Wang, L.; Liu, Y. Sinulolides A–H, New Cyclopentenone and Butenolide Derivatives from Soft Coral Sinularia sp.. Mar. Drugs 2014, 12, 5316-5327.

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