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Correction: Xiao, X., et al. Synthesis, Cytotoxicity and Apoptosis Induction in Human Tumor Cells by Galaxamide and Its Analogues. Mar. Drugs 2014, 12, 4521–4538
Open AccessArticle

Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.

1
Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
2
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
*
Author to whom correspondence should be addressed.
Mar. Drugs 2014, 12(10), 5124-5131; https://doi.org/10.3390/md12105124
Received: 16 May 2014 / Revised: 20 September 2014 / Accepted: 22 September 2014 / Published: 30 September 2014
Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively. View Full-Text
Keywords: gut fungi; Aspergillus sp.; aspochalasin; methylthiol; cytotoxicity gut fungi; Aspergillus sp.; aspochalasin; methylthiol; cytotoxicity
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Liu, Y.; Zhao, S.; Ding, W.; Wang, P.; Yang, X.; Xu, J. Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.. Mar. Drugs 2014, 12, 5124-5131.

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