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Correction: Xiao, X., et al. Synthesis, Cytotoxicity and Apoptosis Induction in Human Tumor Cells by Galaxamide and Its Analogues. Mar. Drugs 2014, 12, 4521–4538
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Mar. Drugs 2014, 12(10), 5124-5131;

Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.

Institute of Marine Biology, Ocean College, Zhejiang University, Hangzhou 310058, China
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
Author to whom correspondence should be addressed.
Received: 16 May 2014 / Revised: 20 September 2014 / Accepted: 22 September 2014 / Published: 30 September 2014
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Two novel aspochalasins, 20-β-methylthio-aspochalsin Q (named as aspochalasin V), (1) and aspochalasin W (2), were isolated from culture broth of Aspergillus sp., which was found in the gut of a marine isopod Ligia oceanica. The structures were determined on the basis of NMR and mass spectral data analysis. This is the first report about methylthio-substituted aspochalasin derivatives. Cytotoxicity against the prostate cancer PC3 cell line and HCT116 cell line was assayed using the MTT method. Apochalasin V showed moderate activity at IC50 values of 30.4 and 39.2 μM, respectively. View Full-Text
Keywords: gut fungi; Aspergillus sp.; aspochalasin; methylthiol; cytotoxicity gut fungi; Aspergillus sp.; aspochalasin; methylthiol; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liu, Y.; Zhao, S.; Ding, W.; Wang, P.; Yang, X.; Xu, J. Methylthio-Aspochalasins from a Marine-Derived Fungus Aspergillus sp.. Mar. Drugs 2014, 12, 5124-5131.

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