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Mar. Drugs 2013, 11(6), 2203-2215;

Conopeptides from Cape Verde Conus crotchii

CIIMAR/CIMAR—Interdisciplinary Centre of Marine and Environmental Research, Rua dos Bragas 289, Porto 4050-123, Portugal
DECM—Department of Engineering and Sea Science, Cape Verde University, Mindelo CP 163, Cape Verde
Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, Porto 4200-465, Portugal
Faculty of Medicine, University of Porto, Porto 4200-319, Portugal
Faculty of Sciences, University of Porto, Porto 4169-007, Portugal
Author to whom correspondence should be addressed.
Received: 1 April 2013 / Revised: 20 May 2013 / Accepted: 27 May 2013 / Published: 19 June 2013
(This article belongs to the Special Issue Marine Peptides and Their Mimetics)
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Marine Cone snails of the genus Conus contain complex peptide toxins in their venom. Living in tropical habitats, they usually use the powerful venom for self-defense and prey capture. Here, we study Conus crotchii venom duct using a peptide mass-matching approach. The C. crotchii was collected on the Cape Verde archipelago in the Boa Vista Island. The venom was analyzed using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). About 488 molecular masses between 700 Da and 3000 Da were searched bymatching with known peptide sequences from UniProtKB protein sequence database. Through this method we were able to identify 12 conopeptides. For validation we considered the error between the experimental molecular mass (monoisotopic) and the calculated mass of less than 0.5 Da. All conopeptides detected belong to the A-, O1-, O2-, O3-, T- and D-superfamilies, which can block Ca2+ channels, inhibit K+ channels and act on nicotinic acetylcholine receptors (nAChRs). Only a few of the detected peptides have a 100% UniProtKB database similarity, suggesting that several of them could be newly discovered marine drugs. View Full-Text
Keywords: Conus; cone snails; conopeptide; conotoxin; Cape Verde Conus; cone snails; conopeptide; conotoxin; Cape Verde

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Neves, J.; Campos, A.; Osório, H.; Antunes, A.; Vasconcelos, V. Conopeptides from Cape Verde Conus crotchii. Mar. Drugs 2013, 11, 2203-2215.

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