Next Article in Journal
Sponge-Derived Kocuria and Micrococcus spp. as Sources of the New Thiazolyl Peptide Antibiotic Kocurin
Previous Article in Journal
(±)-Pestalachloride D, an Antibacterial Racemate of Chlorinated Benzophenone Derivative from a Soft Coral-Derived Fungus Pestalotiopsis sp.
Open AccessArticle

Bioactive Compounds from the Red Sea Marine Sponge Hyrtios Species

1
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
2
Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
3
Department of Medical Parasitology, Faculty of Medicine, Princess Al-Jawhara Center of Excellence in Research of Hereditary Disorders, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
*
Author to whom correspondence should be addressed.
Mar. Drugs 2013, 11(4), 1061-1070; https://doi.org/10.3390/md11041061
Received: 17 February 2013 / Revised: 7 March 2013 / Accepted: 15 March 2013 / Published: 28 March 2013
In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D–F (1–3). Hyrtioerectines D–F belong to the rare marine alkaloids in which the indole and β-carboline fragments of the molecule are linked through C-3/C-3 of both moieties. The structures of the isolated compounds were established based on different spectroscopic data including UV, IR, 1D and 2D NMR (COSY, HSQC, and HMBC) and high-resolution mass spectral studies. The antimicrobial activity against several pathogens and the free radical scavenging activity of the compounds using DPPH reagent were evaluated. In addition, the growth inhibitory activity of the compounds against three cancer cell lines was also evaluated. Hyrtioerectines D–F (1–3) displayed variable antimicrobial, free radical scavenging and cancer growth inhibition activities. Generally, compounds 1 and 3 were more active than compound 2. View Full-Text
Keywords: Red Sea sponge; Hyrtios species; alkaloids; antimicrobial activity; free radical scavenging activity; cancer growth inhibition activity Red Sea sponge; Hyrtios species; alkaloids; antimicrobial activity; free radical scavenging activity; cancer growth inhibition activity
Show Figures

Figure 1

MDPI and ACS Style

Youssef, D.T.A.; Shaala, L.A.; Asfour, H.Z. Bioactive Compounds from the Red Sea Marine Sponge Hyrtios Species. Mar. Drugs 2013, 11, 1061-1070.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop