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The Lipid A from the Haloalkaliphilic Bacterium Salinivibrio sharmensis Strain BAGT

Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy
Division of Immunochemistry, Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Parkallee 10, D-23845 Borstel, Germany
CNR Institute of Biomolecular Chemistry (ICB-CNR), National Research Council (CNR), Via Campi Flegrei 34, 80078 Pozzuoli, Italy
Author to whom correspondence should be addressed.
Mar. Drugs 2013, 11(1), 184-193;
Received: 11 December 2012 / Revised: 9 January 2013 / Accepted: 11 January 2013 / Published: 21 January 2013
(This article belongs to the Special Issue Marine Lipopolysaccharides)
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Lipid A is a major constituent of the lipopolysaccharides (or endotoxins), which are complex amphiphilic macromolecules anchored in the outer membrane of Gram-negative bacteria. The glycolipid lipid A is known to possess the minimal chemical structure for LPSs endotoxic activity, able to cause septic shock. Lipid A isolated from extremophiles is interesting, since very few cases of pathogenic bacteria have been found among these microorganisms. In some cases their lipid A has shown to have an antagonist activity, i.e., it is able to interact with the immune system of the host without triggering a proinflammatory response by blocking binding of substances that could elicit such a response. However, the relationship between the structure and the activity of these molecules is far from being completely clear. A deeper knowledge of the lipid A chemical structure can help the understanding of these mechanisms. In this manuscript, we present our work on the complete structural characterization of the lipid A obtained from the lipopolysaccharides (LPS) of the haloalkaliphilic bacterium Salinivibrio sharmensis. Lipid A was obtained from the purified LPS by mild acid hydrolysis. The lipid A, which contains different number of fatty acids residues, and its partially deacylated derivatives were completely characterized by means of electrospray ionization Fourier transform ion cyclotron (ESI FT-ICR) mass spectrometry and chemical analysis. View Full-Text
Keywords: endotoxin; lipid A; mass spectrometry; Salinivibrio sharmensis; haloalkaliphile endotoxin; lipid A; mass spectrometry; Salinivibrio sharmensis; haloalkaliphile

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Carillo, S.; Pieretti, G.; Lindner, B.; Romano, I.; Nicolaus, B.; Lanzetta, R.; Parrilli, M.; Corsaro, M.M. The Lipid A from the Haloalkaliphilic Bacterium Salinivibrio sharmensis Strain BAGT. Mar. Drugs 2013, 11, 184-193.

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