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Open AccessArticle

New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea

1
School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 101-200, Taiwan
2
Institute of Marine Biotechnology and Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung 80424, Taiwan
3
Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
Mar. Drugs 2012, 10(6), 1321-1330; https://doi.org/10.3390/md10061321
Received: 29 March 2012 / Revised: 18 May 2012 / Accepted: 29 May 2012 / Published: 7 June 2012
Chemical investigation of Junceella juncea has resulted in the isolation of three new briaranes designated juncenolides M–O (13). The structures of these compounds were determined by spectroscopic analysis including 2D-NMR (COSY, HMBC and NOESY) and HRMS. Compound 1 is a new chlorinated briarane while compound 3 contains a rare methyl ester at C-16. The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated. View Full-Text
Keywords: Junceella juncea; briaranes; anti-inflammatory activity Junceella juncea; briaranes; anti-inflammatory activity
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Chang, J.-Y.; Liaw, C.-C.; Fazary, A.E.; Hwang, T.-L.; Shen, Y.-C. New Briarane Diterpenoids from the Gorgonian Coral Junceella juncea. Mar. Drugs 2012, 10, 1321-1330.

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