Next Article in Journal
Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex
Next Article in Special Issue
The Transcriptome of Bathymodiolus azoricus Gill Reveals Expression of Genes from Endosymbionts and Free-Living Deep-Sea Bacteria
Previous Article in Journal
Chemical Profiles and Identification of Key Compound Caffeine in Marine-Derived Traditional Chinese Medicine Ostreae concha
Previous Article in Special Issue
Characterization of a Novel Serine Protease Inhibitor Gene from a Marine Metagenome
Article Menu

Export Article

Open AccessArticle
Mar. Drugs 2012, 10(6), 1192-1202;

Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges

Department of Biochemistry and Biomedical Sciences, McMaster University, 1280 Main St.W, Hamilton, ON L8S 4K1, Canada
Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs Platz 3, 97082 Würzburg, Germany
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Received: 23 April 2012 / Revised: 18 May 2012 / Accepted: 21 May 2012 / Published: 25 May 2012
(This article belongs to the Special Issue Metagenomics in Biodiscovery from Oceans)
Full-Text   |   PDF [682 KB, uploaded 24 February 2015]   |  


Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely substrate. Additionally, a phylogenetically distinct NRPS gene cluster was discovered in the microbial metagenome of the sponge Aplysina aerophoba, which shows highest similarities to NRPS genes that were previously assigned, by ways of single cell genomics, to a Chloroflexi sponge symbiont. Genomic mining studies such as the one presented here for NRPS genes, contribute to on-going efforts to characterize the genomic potential of sponge-associated microbiota for secondary metabolite biosynthesis. View Full-Text
Keywords: nonribosomal peptide synthetase; NRPS; marine sponge; Porifera; metagenomics nonribosomal peptide synthetase; NRPS; marine sponge; Porifera; metagenomics

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Pimentel-Elardo, S.M.; Grozdanov, L.; Proksch, S.; Hentschel, U. Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges. Mar. Drugs 2012, 10, 1192-1202.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Mar. Drugs EISSN 1660-3397 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top