A Scoping Review on Hepatoprotective Mechanism of Herbal Preparations through Gut Microbiota Modulation

Round 1

Reviewer 1 Report

Comments and Suggestions for Authors

The authors have made a thorough review of the available data on the hepatoprotective effects of herbs through regulation of the microbiota. The authors have made an effort to collect information on the topic. The methodology used in preparing this review also deserves appreciation. I have no objections to this manuscript. Congratulations on your good work.

Author Response

Dear reviewer,

Thank you very much for taking the time to review this manuscript. I appreciate your detailed review and valuable insights.

Reviewer 2 Report

Comments and Suggestions for Authors

The literature review, "A Scoping Review on Hepatoprotective Mechanism of Herbal Preparations through Gut Microbiota Modulation," is a valuable work that brings relevant information from the specialized literature to the forefront. Some modifications should be made:

1.      The introduction should be expanded.

2.      Discuss in detail about future perspectives in this research area. Multiple recent articles address topics of interest in the presented theme, specifically microbiota transfer as a potential treatment (more details and relevant articles can be found at https://doi.org/10.3390/biomedicines11041016).

3.      Given the substantial size of the work, the discussion chapter is necessary to discuss contradictions in the literature and to highlight the most important aspects of the review that require detailed comparison with themes from the literature.

4.      The conclusions should be written more concisely.

5.      In the tables, write only the citation number, not the author's name.

Comments on the Quality of English Language

Minor editing of English language required.

Author Response

Dear reviewer,

Please see the attachment.

Thanks.

Author Response File: Author Response.pdf

Reviewer 3 Report

Comments and Suggestions for Authors

The review is well done in term of analysis, however a question related to the parameters was raised. Why the author limits the PICO to animal models (rodent)? are there no studies on humans? why do not include humans' studies to see a comprehensive relation? personally, I would like to see those studies if there are.  Animal studies make not see the real translation of the topic. do humans, mice and rats have same gut microbiota? how different or similar are those? Those are questions that the authors need to solve.  The effects of the herbals are equal in humans than in rodents. That is the main question.

I missed the report doi: 10.1080/10408398.2022.2064423

The authors need to complement the human studies and make in more translational

Comments on the Quality of English Language

few mistakes

Author Response

Dear reviewer,

Please see the attachment below for the responses.

Thanks.

Author Response File: Author Response.pdf

Round 2

Reviewer 2 Report

Comments and Suggestions for Authors

The authors have only partially addressed the presented recommendations.

Author Response

Comments: The authors have only partially addressed the presented recommendations.

Response: The future perspective of this research area has been discussed and highlighted in the discussion section. It can be found on pages 41 to 42, and lines 758 to 798. The author's names in the tables have been removed and replaced with only citation numbers.

Thanks.

Reviewer 3 Report

Comments and Suggestions for Authors

the manuscript is now acceptable

Comments on the Quality of English Language

ok

Author Response

Dear reviewer,

Thank you very much for taking the time to review this manuscript.

 

Round 3

Reviewer 2 Report

Comments and Suggestions for Authors

The authors have made the requested changes.